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THE METHODS FOR PRODUCTION OF AMINO ACIDS AND PROTEINS LABELLED WITH STABLE ISOTOPS 2H, 13C, 15N, 18O

O. V. Mosin

M. V. Lomonosov State Academy of Fine Chemical Technology, Vernadskogo Prospect 86, Moscow, 117571

This given review is devoted to development of modern biotechnological and chemico-phermentation methods on production of amino acids and proteins labelled with stable isotopes 2, 13, 15N, 18. Potential opportunities of these methods for the directed synthesis of isotopically labelled amino acids and proteins are considered. There are submitted data on preparation and further using of synthesized isotopically labelled compounds for various biochemical studies with application of methods of spectroscopy of a nuclear magnetic resonance, infra-red and mass-spectrometry.

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