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Oec a (S)-(+)-eao-2 oye peax, aapyex oaaaopa, papaoa a ocoe ao Pseudomonas sp. 77-33 Pseudomonas sp. 77-47, a oec a (R)-(-)eao-2 - pea, aapyeo oaaaopa, papaoa a ocoe ao Bacillus sp. 77-1 Pseudomonas sp. 59-3. Bxo poyo pacopa oeca coa oaa a. 8.

CH3 OH CH3 (CH2)4CHC C + H O C CHH (CH2)4CHCH3 (CH2)4CHO OAc (R)-(-)-e-2-aea (S)-(+)-eao-C O OH H CH (CH2)4CHCH3 O C CH(R,S)-eao-C C + OH H H (CH ) CH(R)-(-)-eao-2 (S)-(+)-e-2-aea Taa Bxo poyo apoa eaoa-2 aeao oaaaop 30 /; cycpa 10 / a 1 ; oeco o 6.

Oec a Oec a eao-2 e-2-aea Bxo Bxo c Oe- Bxo Bxo c Oeoaaaoce yeo ca oce yeo ca op pac- ee- coa, pac- ee- coa, opa- , % % ee opa- , % % ee , % , % Bacillus sp.

50 40 97 48 45 77-Pseudomonas 49 46 99 50 42 sp. 77-Pseudomonas 48 45 96 50 45 sp. 77-Pseudomonas 50 43 98 49 44 sp. 59-B peyae cooa papaoaoo eoa oec ae eao-2 e-2-aea opayc c xoo 48-50%, o cocae 96-100 % o eopeec oooo o cooecyey oepy. C yeo ee cx poyo xo coca 40-46 %.

9. cceoae cycpao ceoc oaaaopo cceoae cycpao ceoc papaaaex oaaaopo caapx ycox oaao, o o po ocaoo poy ceoc a pa cpa, a eoop aocoepa coee (Ta. 9).

Taa cceoae cycpao ceoc caapx ycox Teepaypa 30 0C, oepa oacc 30 /, oepa cycpao 10 / oepc, % Cycpa 77-1 77-33 77-47 59-1 59-2 59-3 59-Cp eao-2 50 49,2 47 50 51 50 2,3-xoppoao 42,2 80 30 20 100 63,5 epao 65 78 87 80 76 67 ep 0 0 0 0 0 0 Aocoepae cycpa 2-aoya 30,4 51 28,4 32,2 40,9 50 oc yaoa-2 1,1 50 6,8 9,5 5,8 48,9 12,N-3E-e-2-100 0 0 0 0 0 opooyea Ta, apoae eaoa-2, aapyeoe papaoa oaaaopa, po opaoa e-2-aeaa, pe ce a pacoppy cp co cee pepae ~50 % oy paccapac a oeae aoceee oaaaop.

OH OAc OAc CH3CHO B cyae apoa 2,3-xoppoa-1-oa o oapyeo, o a Bacillus sp. 77-1 cocoe pacoppoa aoe coeee c oepce, o 50 % ypo.

OAc Cl OH Cl OAc CH3CHO Cl Cl paec ce cceyee a apoa epao c opaoae epaaeaa, pe ooae oepc yaaoo cpa ocaa 90-95%.

C H O H C H O A c O A c CH CHO p poee epa epa eoo coo eo po oeoo co coc, o cceyee a e aapy ay pea.

peee papaoax oaaaopo poeccax apoa ax aocoepax coee, a 2-aoya oc yaoa2, oaao, o a Pseudomonas sp. 77-33 Pseudomonas sp. 59-3 yceo aapy pepaee yaax coee.

NHNHAc OAc CH3CHO NOH NOAc OAc CH3CHO cceoae pacopa N-3E-ee-2--opooya oaao, o cex ao oo a Bacillus sp. 77-1 cocoe aapoa apoae aoo coee.

NH N Ac CH CHO AcO + + 9.1. cceoae e apoa xpax cycpao cceoae e apoa aeao xpax cycpao ooo oeae aoceee oaaaop poecco eecoo paee paeecx 2-aoyaa (pc. 6,A), eaoa-2 (pc. 6,) 2,3-xoppoaoa (pc. 6,B).

yee poecca apoa 2-aoyaa oaao ae aoc y yx ao Pseudomonas sp. 77-33 Pseudomonas sp. 59-3.

pe, a o pc. 6, oa aa po ey, xapaepy cepeoceeoo poecca, o oeppoa cycpa a 50 %, oce eo oepc cycpaa e eac. oepc 2-aoyaa ae e ac o aao oepa cycpaa, o oe yaa a ae cepeoceex coc y x poopao (c. pc. 6).

Aao coca ae a oaa o ooe eaoy-2, a a Bacillus sp. 77-1 2,3-xoppoa-1-oy, oeppy cycpa a 50 %.

A 10 0 5 10 15 20 25 30 35 40 45 0 5 10 15 20 25 30 35 Bpe, Bpe, B 0 5 10 15 20 25 30 Bpe, .

5 / 10 / Pseudomonas sp. 77-33, Pseudomonas sp. 59-3, Bacillus sp. 77-Pc. 6. Tpacopa xpax cycpao papaoa oaaaopa:

A - ea apoa 2-aoyaa, - ea apoa eaoa-2, B - ea apoa 2,3-xoppaoa ao Bacillus sp. 77-Bpe pea 29-50 aco, eepaypa 30 0C, oepa cycpao 10 / 10. Papaoa peapax eoo oye paec ex eec 10.1. oyee oec aoo eaoa-C cooae cxe, pecaeo a pc. 5, papaoa eo oye (S)-(+)-eaoa-2 (R)-(-)-eaoa-2, oope c ae oec a coo, a ae oopoo oe cepoa e ooec eoac ce ooo epoo ya-oa Nediprion lecontei.

oepa eaoa-2, / oepa 2-aoyaa, / / oepc 2,3-xoppoaoa, Oec a (S)-(+)-eao-2 oye peax, aapyex oaaaopa a ocoe ao Pseudomonas sp. 77-33 Pseudomonas sp. 77-47, a oec a (R)-(-)-eao-2 peax, aapyex oaaaopa a ocoe ao Bacillus sp. 77-1 Pseudomonas sp. 59-3 (a. 10):

OH OAc (S)-(+)-eao-2 (R)-(-)-e-2-aea OH OAc (R,S)-eao-OH OAc (R)-(-)-eao-2 (S)-(+)-e-2-aea Taa Bxo poyo apoa eaoa-2 aeao oaaaop 30 /; cycpa 10 / a 1 ; oeco o 6.

Oec a Oec a eao-2 eao-2-aea Bxo Bxo c Oe- Bxo Bxo c Oeoaaaoce yeo ca oce yeo ca op pac- ee- coa, pac- ee- coa, opa- , % % ee opa- , % % ee , % , % Bacillus sp.

49 43 99 50 40 77-Pseudomonas 50 45 100 50 46 sp. 77-Pseudomonas 49 40 97 48 42 sp. 77-Pseudomonas 48 42 98 49 40 sp. 59-B peyae cooa papaoaoo eoa oec ae eao-2 e-2-aea opayc c xoo 48-50%, o cocae 96-100 % o eopeec oooo o cooecyey oepy. C yeo ee cx poyo xo coca 40-45 %.

10.2. eecoe paeee 2,3-xoppoaoa Oece oep 2,3-xoppoaoa c ae coa oye eapc (-oaop), ao, epooo aceox, a ae eppoepecx pcao. B c c c cooae oaaaopa a ocoe aa Bacillus sp. 77-1 papaoa eo oye oec aoo (R)-(-)-2,3-xoppoaoa coo oeco co (a. 11).

Cl OH Cl OH Cl OAc H Cl Cl H Cl (R)-(-)-2,3-xoppoao 2,3-xoppoao (S)-(+)-2,3-xoppoaea Taa Peya apoa paeecoo 2,3-xoppoaoa aeao oaaaop 30 /; cycpa 10 / a 1 ; oeco o 6.

(S)-(+)-2,3(R)-(-)-2,3-xoppoao xoppoaea Bxo Bxo c Oe- Bxo Bxo c Oea oce yeo ca oce yeo ca pac- ee- coa, pac- ee- coa, opa- , % % ee opa- , % % ee , % , % Bacillus sp.

50 43 97 49 45 77-10.3. Ce epaaeaa Pae p epaoa poo pec oceeco poeoc oye pax oye apoaecx oao. B c c papaoa eo cea epaaea epae epaoa aeao ecae pcyc papaoax oaaaopo (a. 12).

Taa Peya epa epaoa oaaaop 30 /; cycpa 10 / a 1 ; oeco o 6.

oepc epaoa, Bxo epaaeaa, oaaaop % % Bacillus sp. 77-1 91 Pseudomonas sp. 77-33 98 Pseudomonas sp. 77-47 87 Pseudomonas sp. 59-3 88 oaaaop a ocoe ao Pseudomonas sp. 77-33, 77-47, 59- Bacillus sp. 77-1 aapy opaoae epaaeaa eee aco c xoo 90-95 %.

BBO 1. B peyae cpa ppox coo ee epoa poopa Pseudomonas sp. 77-33, 77-47 59-3, oaae coo cepao aoc.

2. Papaoa cpecc-eo cpa poopao, cepyx epe, aapye apoae cpo opaeco pacopee, oop ocoa a cooa aapox oo c poc a x yypa poopao.

3. Ha ocoe ao Bacillus sp. 77-1, Pseudomonas sp. 77-33, Pseudomonas sp. 77-47 Pseudomonas sp. 59-3 papaoa aoceee oaaaop apaoo apoa cpo. caoeo e apaepo poca oacc pacopa a aoc oaaaopo, e yco xpae a x caoc. oaaa oooc oopaoo pee coax oaaaopo eee eoo pee.

4. peoea paa exooeca cxea oye aoceex oaaaopo apaoo apoa cpo.

5. Papaoa eo paee paeecx eaoa-2 eaoa-2 ye x apaoo apoa aeao, ooe oya c co (70 80 %) xoa (S)-(+)-eao-2, (R)-(-)eao-2 (S)-(+)-eao-2, (R)-(-)-eao-2 coo oeco co (97-100 % ee).

6. Papaoa eo apaoo apoa paeecoo 2,3xoppoaoa, oo oya (R)-(-)-2,3-xoppoao coo oeco co (97 % ee).

7. Papaoa oaaec eo apoa epaoa x ycox, oo oya epaaea c co xoo (95 %).

8. Ha ocoe poeex cceoa ayo oocoaa paa exooeca cxea oye oec ax coo ooeypx opeyopo ycx eec: (S)-(+)-eaoa-2, (R)-(-)-eaoa-2, (S)-(+)-eaoa-2, (R)-(-)-eaoa-2, (R)-(-)-2,3xoppoaoa epaoaeaa.

Cco pao, oyoax o ee ccepa 1. eyxoa H.., ooao A.A., Myapao A.., op B. B. oc poopao - poyeo oecx epeo // Maep. 49 ay.-ex. o. cy., ac. oo. y. a: -o HT, 1998. - C. 156.

2. eyxoa H.., ooao A.A., Myapao A.., op B. B. Beee oecx epeo x peee cee oec ax coee // Maep. 49 ay.-ex. o. cy., ac. oo. y. a: o HT, 1998. - C. 31.

3. Myapao A.., ooao A.A., Meeep C.B., apaoa .B., eyxoa H.., op B.B. oc poopao, xc oaaaopa poeccax paee paeecx cece aoepo opx cpo // Maep. XXXVII Meyap. ay. cy. o. Hoocpc, 1999. - C. 134.

4. Myapao A.., ape A.A., eyxoa H.., op B.B. Cp poopao apoa opx cpo opaecx pacopex // Maep. XXXVIII Meyap. ay. cy. o. Hoocpc, 2000. - C. 109-110.

5. Myapao A.., eyxoa H.., op B.B. Mpoooecoe apoae opx cpo // .. ao copeee poe oo e: Maep. o. a, 1999. - C 31.

6. ape A.A., Myapao A.., eyxoa H.., op B.B. eca poecca paee po opx cpo // Maep. 51 ay.ex. o. cy., ac. oo. y. a: .-o. HT, 2000. - C. 111.

7. Myapao A.., Meeep C.B., eyxoa H.., op B.B. eca poecca apoa opx cpo aa poopao. // Pea-99: Maep. XII Meyap. o. o po. pe.

x. pea. pea. a-M., 1999. - C. 72-73.

8. Myapao A.., Meeep C.B., eyxoa H.., op B.B. cceoae apoa opx cpo ea poopao opaeco pacopee // Cepc ooo opoa: Meyap. ay.-pa.

o. a, 1999. - C. 45.

9. Myapao A.., eyxoa H.., apee B.M.,op B.B. oc ox pox oaaaopo aoceeoo apoa eaoa-2 // X. 2000. - T. 7. 5. C. 37-39.

10. Myapao A.., eyxoa H.., op B.B. Apoae opx cpo opaeco pacopee c oo eo poopao // oexoo epa: Maep. ao. ay.-pa. o. C, 1999. - C. 55.

11. Myapao A.., ape A.A., eyxoa H.. op B.B. apaoe apoae opx cpo p oo poopao // Ayae ee opaeco cee a opoe oo p: Maepa opo eyapoo oepe oox yex. Ca-eepyp, .

C.-, - 1999, c. 75;

12. Myapao A.., ooao A.A., Meeep C.B., eyxoa H.., op B.B. Paeee paeecx cece cpo c oo oecx poopao // Heex-99: Maep. V Meyap. o. o ec.

eex. po. Heac, 1999. - C. 96.

13. Myapao A.., ape A.A., eyxoa H.., op B.B. Apoae epaoa pcyc a poopao // Pea-2000: Maep.

XIII Meyap. o. o po. pe. x. pea. pea. a-M., 2000.

- C. 66.

14. Myapao A.. Apaoa .. Aoo epaoa -3ocypao // Cye ayo-exec popecc: Maepa XXXIX Meyap. ay. cy. o. - Hoocpc, 2000. - C. 57-58.

15. Myapao A.., eyxoa H.., op B.B. epa eaoa-opaec coa // Pea-2001: Maep. XIII Meyap. o. o po. pe. x. pea. pea. - a-M., 2001. - C. 52.

16. Myapao A.., eyxoa H.., op B.B. oaaecoe oyee oec ax coo ooec cx cpec op c aceo pee cecoxocex yyp // Xeca oo: Maep. .-ce. a: .-o. a, 2001. - C. 76.

17. op B.B., eyxoa H.., ooao A.A., Myapao A.., Papaoa aoceex eoo paee paeecx cece cpo po c cooae eo poopao // Haye cceoa ce o oac x xecx poyo: Mey. c. ay.

p. Moca, 2001. C. 81-86.

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