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Ha a paccopea pea aaecoo aoec ypaa 35 c aocoeee 6, c e oye cooecyeo opoaa, coepaeo aocoay pyy (cxea 9). M a, o p o poeae apaeo pcoeee paceee eepoa opayc ceye coee: opoo p o(2-ocao-[3.1.0]-ec-3-e-6-)ocopo co 36 p cepeooepx eo - opoo p (5-ocoea-1(E),3(Z)e)ocopo co 37, opoo p (5-ocoea1(Z),3(Z)-e)ocopo co 38, opoo p (5ocoea-1(Z),3(E)-e)ocopo co 39, opoo p (5-ocoea-1(E),3(E)-e)ocopo co 40.

O HP(OiPr) H H O O H P(OiPr) O (E-Z)-O O P(OiPr) KAT (iPrO)2 P + H CH NO O (Z-Z)-35 O O H P(OiPr) (Z-E)-O H O P(OiPr) (E-E)-Cxea Ha o cceoao e ppo aaaopo a coca cpoee poyo aoec ypaa 35 c aocoeee (a. 5).

Taa Be ppo aaaopa a xo poyo pea aocoee 6 c ypao (Pacope - CH2Cl2).

aaaop Mooe Bpe Tee- O xo coooee pea, paypa poyo, peaeo pea, 36+37+38+39+o a.:6:35 C % 0.02:1:3 3 0 28 (1:0.3:0.1:0.4:1) Cu(OTf)*C6H 0.01:1:6 1 0 40 (1:0.2:2.4:0:0.8) 0.02:1:3 3 0 42 (1:0.3:1:0:1.4) Cu(OTf) 0.01:1:6 1 0 40 (1:0.1:2.3:0:0.7) Cu-poa 0.01:1:3 8 0 23 (1:0.3:0:0.1:2.6) In(OTf)3 0.02:1:3 18 0 - Cu(acac)2 0.01:1:6 1 50 42 (1:0.1:0.3:2.4:0.2) Rh2(AcO)4 0.05:1:6 1 50 25 (1:2.3:0:0:4) oyex ax (a. 5) ceye, o ay aaaopa c Cu(OTf)*C6H6 Cu(OTf)2. p x cooa o xo oex poyo opoaa 36 eo 37-cocae 42%-40%. eee pooeoc pea, aapyeo Cu(OTf)*C6H6, c ooo aca o pex po ce cyapoo xoa poyo pea o 28%. Booo o pocxo -a oo- oepa eo. Cxo peya (xo poyo 42%) ocy p cooa aece aaaopa Cu(acac)2, o p o eoxoo apea o 50oC. He xo, (ceo 23% 25%) oex poyo, oye peax aapyex cooeceo Cu-poa Rh2(AcO)4, oa a In(OTf)3 aaecoo e oaae. Tao peya oe ca c e, o In(OTf)3 e cyae pea pcoee c aoocoao 6, a o pocxo y pyx coyex a aaaopo. Oe, o cyap xo eo 3-3.5 paa e, e opoaa (a. 5).

2.3. Cepeocee ce opoocoaa.

Bcoa ooeca aoc opoocoao cypye papaoy yox eoo oye x eec.

M poe pexca ce poccoepaeo opoocoaa, cxo poeo ocyoo ooo pa eocopo co 41 (cxea 10).

epa ca aaec apoa ypaoo peaea, oyeoo peaea 41, 5-ee-2E-e-1-poo42. M a yco (-35oC, 5 aco), oopx xo ooo pa(6-e-ec-3-e)ocopo co 43 cocae 82%.

1. n-BuLi, (-20oC) O O EtO EtO 2. CuI, (-60oC) P CH3 P EtO EtO Ph CH2Br 3. Ph, (-35oC) O COOH Cl O EtO P EtO Ph O n-BuLi, (iPr)2NH O EtO H(3) P EtO Ph H(1) OH Cxea ocpoae oo yepo-yepoo c coee -xopaeoo coo CH2Cl2 (23-25oC, 4 aca) peo cooecyey ocy 44 c xoo 95%.

oce (pe) ca epepypoa eooo pa [2-(3-poocpa)e]ocopo co 44 o ece opoaa ooa ceeo oy eeo aee poccoepa opoa 45 mpac-oypa c xoo 50 %. Pea ocyecac T (-78oC, 1 ac ae p 23-25oC, 2 aca).

Cepeox coee 45 ycaoea o a MPcepoco. B MP-cepe eeoo poya 45 aaec ca pooa H(3) p aoe C(3) oac 1.32-1.53 .. e yea c ocao JP-H3=16.32 . o yaae a eo mpacpacooee o ooe paey PO(OEt)2 ocoy epaypx ax eco, o opoocoao c mpacoypae ocaa c-cooo aoec JP-H3 axoc aaoe 14.5- 20 .

Bo 1. caoeo, o aapyeoe oeca eao pcoeee opoooo pa aoeocopo co o oo c yepo-ao eeeaa poeae c opaoae uc- mpac-oepo opoooo pa (1,3-eap-2-)ocopo co. Bxo apa eo oypa opeec, epy oepe, o coyeoo aaaopa. ya uc-oep opayec pcyc In(OTf)3 p 0oC. oo poyo pea ec aea, xo oopoo ae p cooa aece aaaopa Cu(OTf)2.

2. oaao, o xoe aaecoo aoec opoooo pa aoeocopo co c a xo pocpaceoe cpoee, opayxc apo, cyeceo ac o a aece apoaeco pe a. Ta epoo-aeope CF3- NO2-py apa- ooe apoaecoo oa ca cepeoceeoc oepa uc-oepa oo 2 paa peae coepae mpac-op.

3. ppoae eooo pa uc-4[1-ep-3(opoococop)ap-2-]ycyco co eaoe pcyc aaaopa (10% Pd a ye) p 23-25oC poeae c cee papo yepo-aoo c co copo apoaecoo pa opaoae epo aopy. eeo ocopcoepa a oye c xoo 79% eo po 6N HCl pe cooecyey poxop[1-ao-2-(4-poce)-1-]ocopo co c xoo 87%.

4. Baoece opoooo pa aoeocopo co c ypao pcyc eaooecx aaaopo p 0-50oC poeae apaeo c coxpaee paceee eepoa po opaoa cooecyx opoaa eo pao oypa.

y xo poyo pea (40-42%) ocy p cooa aece aaaopo Cu(OTf)2 Cu(acac)2. p o cyap xo eo 3-3.5 paa e, e opoaa.

5. cxo poeo ocyoo ooo pa eocopo co ocyece pexca ce ooo pa mpac-[2-(1-poc-3-epo) opo]ocopo co. eo cae ec cepeoceea oepa eooo pa [2-(3-poocpa)e]ocopo co pcyc n-BuLi (iPr)2NH. Cyap xo eeoo ocopcoepaeo opoaa a ocoa cocae 50%.

Ocoe peya ccepaoo pao oyoa ceyx cax ecax oao:

1. yeoa H.., Aop ., eap P. aaecoe aoece opoaoe c eeeao. // a. x. ypa. - 2002. -T. 2, 3.- C. 36-37.

2. yeoa H.., Aop ., eap P. Ce aeex opoocoao. // a. x. ypa.-2002.T. 9, 3.-C.41-42.

3. yeoa H.., Aop ., eap P. Ce ocopcoepax apo. // Tec oao XV Meyapoo ayoexeco oepe Xece pea, peae poecc aooao x. a, 2002. - C.125.

4. yeoa H.., Aop . aaecoe aoece opoaoeocoaa c N-eeao. // Tec oao Bcepoccco aoo oepe aa oexoo, x xecx exoox. Tep, 2002. - C.57.

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