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Ha paax pyoc OHOBAOB AHPE AECAHPOB PAPAOTA METOOB PAEEH PAEMECX POB C OMO POA MPOOPAHMOB Ceaoc 03.00.23 oexoo ABTOPEEPAT ccepa a cocae yeo cee aaa execx ay a 2002 2 Paoa oea co ocyapceo eo execo yepcee.

Haye pyooe: oop xecx ay, poeccop op Bap Bopo;

aa ooecx ay, oe eyxoa Haea aoa.

Oae ooe: oop ooecx ay, poeccop Meee Aecap ao;

aa execx ay Tepexoa Eea oea.

Beya opaa apc ocyapce yepce.

aa cococ 25 eap 2002 oa 1000 a acea ccepaooo coea 212.289.06 p co ocyapceo eo execo yepcee o apecy: 450062, Pecya aopoca, . a, y. ocoao, 1.

C ccepae oo oaoc oee coo ocyapceoo eoo execoo yepcea.

Aopeepa paoca "25" op 2002 oa e cepeap ccepaooo coea Caoo H.A.

3 OA XAPATEPCTA PAOT Ayaoc cceoa. B acoee pe oc ox cooex eapcex cpec, oaax apae ece oeo ococ, a ae ooec ax eec, coyex coa ooec cx eoo a pace ocyecec cpe ppox coee x opoax ceecx aaoo. Moe x e ceecy cepeox, oycoey ae ox ce xpax epo. coa eoo oye ceecx aaoo ppox coee eoxo oec ae o. ae epec aece ax oo peca oec ae cp, ocapooe co x p.

Cepeoapae ce paeee oecx oepo xec eoa pecae coo coy opoocoy aay, cece eo ocoeo epce ec poooec oxo, ocoa a cepeoapaeo opacopa opaecx coee. B py epeao aapyex pea oco epec pecae aocee po paeecx po, aapye oec poopaa, a a a c oepeeac, po poy cycpay ceoc, coy cepeoceeoc caoc. poe oo, ocoeoc a, ec x cocooc aapoa pea epa pacepa opaecx pacopex, oope poo coyc p oye oec ax coee. B c c oc ox ex poopao, coepax cepeocee poa c e coa a x ocoe oaaaopo aoceeoo cea oec ax cpo, occo x po ec ayao aae.

ccepaoa paoa oea cooec c aae Mcepca opaoa P o eaecoy ay HP coo ocyapceoo eoo execoo yepcea (HT): eepao eeo popao ocyapcea oepa epa ceo opaoa yaeao ay (1997-2001 .); ayo-execo popao Haye cceoa Bce o o pope apae ay ex 1998-2002 .

e pao Papaoa ox cooex oaaaopo poa paeecx po a ocoe poopao, oaax poao aoc, coae eoo oye oec ax cpo, po occo.

B cooec c ocaeo e peac ceye aa:

cp poopao eeox epeo, oaax coo poao aoc cocox ocyec aocee po paeecx po opx cpo occo;

cceoae opooecx, ooo-oxecx aoex coc aex poopao;

papaoa aoceex oaaaopo apaoo poa po a ocoe eo poopao;

oa oaaaopo c e yee x caoc, aoc cpoa xpae;

oc oax yco poca oacc pao oaaaopo p poe po;

cceoae oooc cooa aex oaaaopo aoceeoo aoa, aooa aooa opaeco pacopee;

papaoa eoo paee paeecx po oo opaeco cpeax c oo coax oaaaopo.

Haya oa. Hae epoa 3 ox eaoex aa: Bacillus sp. 77-1, Bacillus sp. 79-54 Rhodococcus sp. 78-5, a ocoe oopx coa cepeoceee oaaaop, eo aapye a po po paeecx cpo occo oo cpee, a aoo, ao aoo x coee opaeco ae. Papaoa ayo oocoae eo cea oec ax cpo, occo x po c cooae coax oaaaopo. Hae yco, oopx oaaaop po acy aoc. oaaa coa caoc oooc oopaoo cooa papaoax oaaaopo.

paeca aoc. Papaoa oe cooee oaaaop a ocoe ao Bacillus sp. 77-1, Bacillus sp. 79-54, Rhodococcus sp. 78-5 aoceeo aapye a po po paeecx cpo occo oo cpee, a aoo, ao aoo x coee opaeco ae. Coa peapae eo oye (S)(+)-op-yaoa, (R)-(-)-op-yaeaa, (S)-(+)--3-ocypaa, (R)-(-)-3-ocypaa, (S)-(+)-3-ocaco co, (R)-(-)-3-ocaco co, (S)-(+)- oa (R)-(-)-oa coo oeco co (96 %ee), oope c e coa p oye pax ooeypx opeyopo (epooo aceox, -apeepeo, epepoo, opoo, pocaao, yeoo,) opaaaex oepo. Meoa paee paeecx op-yaeaa, -3-ocypaa ooo pa eapoo co coyec yeo poecce HT p oooe eepo o ceaoc 07.01.00 oexoo.

Apoa pao. Peya cceoa oaac a II Meyapoo oepe Ayae ee cee a opoe oo p (Ca-eepyp, 1999); V Meyapoo oepe o eca eexecx poecco Heex-99 (Heac, cep 1999);

XXXVII Meyapoo Hayo cyeeco oepe (Hoocpc, ape 1999); 49 ayo-execo oepe cyeo, acpao oox yex (a, ape 1999); Meyapoo ayo-paeco oepe Cepc ooo opoa (a, a 1999); XII Meyapoo oepe o poocy pee xecx peao peaeo Pea99, (a-Moca, cep 1999); Pecyaco ayo oepe ..

ao copeee poe oo e, (a, op 1999);

aoo ayo-paeco oepe "oexoo "epa", (Ca eepyp, 1999); XXXVIII Meyapoo ayo cyeeco oepe (Hoocpc, 2000); XIII Meyapoo oepe o poocy pee xecx peao peaeo Pea-2000, (a-Moca, 2000); XXXIX Meyapoo ayo cyeeco oepe, (Hoocpc, 2001); 51 ayo-execo oepe cyeo, acpao oox yex. (a, 2001).

ya. o aepaa ccepa oyoao 3 ca ec 16 oao.

Cpyypa o pao. ccepa ae eee, oop epayp (aa 1), ocae oeo eoo cceoa (aa 2), ocyee peyao (aa 3), o cco pyeo epayp, coepa 135 aeoa. Paoa oea a 145 cpaax aocoo eca coep 35 pcyo 32 a.

TEPATPH OOP 1.

yee epaypx coo oaao, o cepeoapaea opacopa opaecx coee aa ec oo aoee epcex eco papaaaex oace copeeo oexoo CA, o cpaax aao Epo. Oao, oeco epex peapao , ocoeo, oaaaopo a ocoe ax eo poopao, oox oya coee coo oeco co (95-100% ee) eeo o e yepca.

Bcece oo cyecye eoxooc oca ox oecx poopao, cocox aapoa aocee po paeecx po, a ae coa ox eoo oye oec ax eec a x ocoe.

OET, MATEPA METO CCEOBAH 2.

Oea opacopa c oece poopa cepye eeoe ypeoe a, eee oex opao, x c pax yaco xecx pooc Pecy aopoca Cp, a ae op-yaea, -3ocypa, o p eapoo co N-3E-ee-2-opooy aea. p poee cceoa cooac oxece eo cceoa, a ae copeee o-xece eo aaa MP (13C, 1H), xpoaoacc-cepoep.

PETAT OCEHE 3.

3.1. Cp oecx poopao oeax coo aoceex epeo oc oaaaopo, cocox aoceeo ocyec po paeecx po cpo occo pooc cooec co cxeo pecaeo a pcye 1.

aoex yyp, oyex a o cpee CP-1 c oo aco aece eceoo coa yepoa ep, ee 145 aepax ao, oope a aapoao cpee c poao 6G poecce poca aaa pe co opaye opae oec c pacee. p paoe c c yypa x poopao oapye 29 ao, opayx eeoe e poecce poca a o cpee CP-1.

B peyae cceoa poa oooo aca peapaa eeox eo x poopao a ea oeca aoc y 5 epex peapao. poe oo, a oapyea oeca aoc eo y cex 145 ao.

opa no oyee aoex yyp poopao a epao cpee c oo aco aece eceoo coa yepoa ep - CP-36 aonumex ymyp Beee cx yyp poopao a aapoao cyce Opeeee poopao cepyx oece epe a aapoao CP-1 c poao 6G 145 mao Oop ao cepyx cceoae oeco aoc eeoe e eo poopao 29 mao cceoae oeco aoc peapao eeox eo 145 mao epeme npenapam 5 mao cceoae oepc poa cceoae oepc poa op-yaeaa -3-ocypaa 0% - 40% 60% - 100% 0% - 40% 60% - 100% 40%-60% 40%-60% 86 mao, 45 mao, 80 mao, 17 mao 14 mao 11 mao epem epeme epeme npenapam npenapam 4 npenapam 1 maa mao mao Pc. 1.

Cxea cpa poopao oeax coo aoceex poa:

Caape yco poa: cpea - 0,05 M oca yep pH = 7,0; pe pea - 5 .;

aaa oepa cycpaa - 5 /; eepaypa - 30 0C. B cyae poa op-yae aa oe pacopoc pea oc aeo 20 % o.

cceoae cocooc aex epex peapao eo poopao pacoppoa paeec op-yaea -3ocypa eee 5 aco ooo oopa a, poye coee c oepce o 50% ypo (14 11 ao, cooeceo), o cooecye eopeec oooy xoy poeccax eecoo paee paeecx cece opaecx coee.

3.1.1. cceoae pacopa op-yaeaa yee e poa op-yaeaa ae poopaa eee 10 aco oaao, o 10 ao coxpa ocy 5 aca ypoe oepc, oa a 4 aa pooa oeppoa cycpa ae.

caoeo, o po ocao oepc cycpaa a 50 % ypoe e cao c poae aoc eo, ocoy eee opo op cycpaa po eo pacopa c o e copoc o oo e ypo pepae, o I e. oee epoo po eooo pepae op-yaeaa ec cepeocee po epea poopao ooo aoepo paeeco cec, oa a opo aoep e oepaec pacopa.

77-1 77-28 77-25 77-34 77-38 77-39 77-47 79-54 79-58 79-a Pc. 2.

ea aoc poopao, aapyx po op-yaeaa co pea: pH= 7,0; t=30 0C; pe 5 ; aaa oepa cycpaa 5 /.

yee oecx coc poyo pea 7 aoee ax ao aapyx po op-yaeaa co copoc ce 25 /(ac) (pc. 2): 77-1, 77-25, 77-28, 77-34, 77-39 79-54, 79-59 oepo peya eecx cceoa. o oapyeo, o ce 7 ao aoceeo poy (S)-oep (R,S)-op-yaeaa (a. 1).

Me Me OH Et O 77-1,77-25,77-28,77-34, 77-39,79-54,79-59 C C + O H Et H OAc (R)-(-)-Bop-yaea (S)-(+)-Bop-yao.

(R,S)-Bop-yaea ea /((ac) ) aoc, Taa Bxo oeca coa poyo pacopa co pea: pH= 7,0; t=30 0C; pe 5 .; aaa oepa cycpaa 5 /.

a Bop-yaea Bop-yao Bxo, Oeca c- o- Bxo, Oeca o%* oa, % ee ypa %* coa, % ee ypa 77-1 100 96 R 100 97 S 77-28 100 86 R 100 90 S 77-25 100 90 R 100 77 S 77-39 100 51 R 100 71 S 79-54 100 99 R 100 98 S 79-59 100 52 R 100 75 S 77-34 100 46 R 93 64 S *- a 100% xo p eopeec oo xo poya p yaao oepc paeecoo cycpaa.

p o aoee ce poy c oece xoo opayc p cooa ao 77-1 79-54 (a. 1).

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