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Ha paax pyoc opae Bap Bapo Papaoa exoo epepao aocoepax oxoo pooca 4-e-2,6--pe-yeoa c oyee poyo aooao x Ceaoc 02.00.13 Heex Aopeepa ccepa a cocae yeo cee aaa execx ay a 2002 2 Paoa oea a aepe "Oa xeca exoo" coo ocyapceoo eoo execoo yepcea Hay pyooe oop execx ay, yae H.C.

Oae ooe oop xecx ay, poeccop aop E.A.

aa xecx ay, paco B.A.

Beya opaa AO ayc aa ccepa cococ " " 2002 . .

a acea ccepaooo coea 212.289.01 p co ocyapceo eo execo yepcee o apecy:

450062, . a, y. ocoao, 1.

C ccepae oo oaoc oee coo ocyapceoo eoo execoo yepcea.

Aopeepa paoca " " 2002 .

cepeap ccepaooo coea poeccop A. M. Cp 3 Oa xapaepca pao Ayaoc e : B ocox apaex ooecoo coaoo pa P a ae o peycapaec yeee pacpee yca oeayp aooao xeco poy, pee ceo poy opaecoo cea.

Poc opee oepo peye pa x exoo pooca caaopo, ye papao ox cocoo oye capyx oao c cooae oox poyo pyooax xecx pooc. O yea cpo cy oepo, oa x ceo- epocaoc, o opeee x aeco cyaaoe coca.

Ta, p pooce ooo cax pacpocpax caaopo 2,6--pe-y-4-eeoa (ooa) a ca aoepoa 2,6--pe-yeoa opayec aeoe oeco aocoepax oxoo, ax ce ae coee a ea, N,N-epaeeea, 1,3,5peecapo-1,3,5-pa, pea, eao.

B c c ca opoc o paeco cooa ax oxoo aece cpeo a cee aocoepax coee, oaax cooyoc ex oex coc. B x ce oy pocpaceo-apye pocea, eoe ocoa Maxa, op oppo, aep, cepocoepae ycope yaa.

Oao acoee pe aocoepae oxo pooca ooa e axo apoaoo pee.

Ta opao, epepaoa aocoepax oxoo oyee poyo aooao x, oaax oeco oex coc, pacpee x pee ec ayao poeo opaecoo cea.

Paoa oea cooec c ayo-exec popaa P o aye cey opaoa "ocoe pae poe epepao e, aa y" yepo pao P o aye cey opaoa 124 o 06.11.92, "oecoe peee poe pae, pacoppo, yoo epepao e aa", yepo pao P o aye cey opaoa 468 o 20.03.96.

e pao. e cceoa oc peee ayopaeco aa - papaoa exoo epepao aocoepax oxoo pooca ooa (2,6--pe-y-4-eeoa) c oyee pocpaceo-apyex eox ocoa Maxa, opo oppo, aepo, ycopee yaa, oc oace x eoo paecoo cooa.

Haya oa. cceoa coco oye N,N-e-(3,5-pe-y-4-poce)-aa a ocoe aocoepax oxoo pooca ooa. Opeee oa eepaypopeeo pe oye N,N-e-(3,5--pe-y-4poce)-aa.

cceoaa ea pea epeapoa N,N-e-(3,5-pe-y-4-poce)-aa 1,3,5-peecapo-1,3,5pao c oyee c-N,N-(3,5--pe-y-4-poce)eaa. oaaa acoc xoa eeoo poya o opoc peeoo pacope.

Bepe cepoa eoapaa a S-(3,5--pey-4-poce)eoapaa aocoepax oxoo. cceoaa acoc copoc pea aoepoa 2,6--pe-yeoa o oepa pacope.

paeca eoc. Papaoa oe coco oye aocex pcao aocoepax oxoo o eoc peocxoe caap-oo.

caoeo, o aocoepae oxo pooca ooa coco eo oa poc cyaoccaaax aep.

Ha x ocoe papaoa peeype coca ox aoppoox peapao -1 -2. Beo, o ae peapa ae eo oa poc cyaoccaaax aep.

Ha Cepaaco eexeco aoe yea oa ap peapaa "-1".

a paece peoea o epepaoe aocoepax oxoo pooca ooa.

Apoa pao. Peya pao oaac a eyapoo oepe "eepa aa opyae cpe" .Moca, M, 2001 ., a ayo-paeco oepe "Ayae poe Boo-paco eeaooco po" .e, 2001., "III opecce eeaopoeoc Pocc" .e, 2001., II Meyapoo ayo oepe "Teop paa accooex poecco xeco exoo" .e, 2001.

ya. o aepaa pao oyoao 2 ca ypae, 7 eco oao a oepex.

O pao. ccepa oea a 117 cpaax aocoo eca coco ee, epex a, oo, cca coyeo epayp. ccepa coep 16 pcyo, 13 a, 107 cco a ya oeecex apyex aopo.

Ocooe coepae pao epa aa ocea oopy epayp. B e oe aye oce oac cea cooa eox ocoa Maxa, aocoepax aepo opo oppo. Ha ocoa aaa epaypx ax copeeoo coco paccapaeo oac xeco poeoc oocoa e aa cceoa.

Bopa aa coep ocae oeo eoo cceoa poceao.

B pee ae poc peya cepeo o cey opo oppo, aepo x ocyee.

1 Ce eoopx poceao 1.1 Papaoa oax yco oye N,N-e-(3,5-pe-y-4-poce)-aa p oye 2,6--pe-y-4-eeoa poea pae pea apoae, aoepoae, poeo p. Oao, oo ocox pea e eco ooe c opaoae peaa, 1,3,5-peecapo-1,3,5-paa p. ocya a ye cea N,N-epaeeeaa (caa) opa coep coe cocae 5-9% eaoa, oop ocoo aaaec ccee cococye opaoa oox poyo c ya aoepoa 2,6--pe-yeoa ceyeo cocaa, acc %:

pea 0,01-1% ea 7-15% N,N-epaeeea 18-30% 1,3,5-peecapo-1,3,5-pa 0,5-3% oa 1-10% eao 40-70% Ce 2,6--pe-y-4-eeoa ocaec ceye peae:

OH OH OH OH (CH3)3C C(CH3)(CH3)3C C(CH3)3 (CH3)3C C(CH3)(CH3)2NCH2N(CH3)i C4HHcat, t cat, t CH2N(CH3)CHpooc cceoa o oye oxoo yaaoo pooca eox ocoa Maxa, xc e pcaa o, ace ayyo.

Ha poecc aoepoa 2,6--pe-yeoa, c oyee N,N-e-(3,5--pe-y-4-poce)-aa oe aop: pe eepaypa pea, coca aoepyeo aea.

C e opeee oax apaepo poecca oye N,N-e-(3,5--pe-y-4-poce)-aa poee cepeae cceoa c ec eepaypopee apaepa.

caoeo, o poecc aoepoa ee opa xapaep ec xoe pea eapoa ea po opaoa 1,2--(3,5--pe-y-4-poce)-aa, c-(3,5--pe-y-4-poce)-eaa, 3,3,5,5-epa-peycexoa. ce opao pea oe xoa N,N-e-(3,5--pe-y-4-poce)-aa peoeo eee pea opaea, oop epye 2,6-pe-yeo, ec xoe pea eao.

Beee pea opaea ooe, poe oo, c exooeco cxe poecca ye yaa eaa.

cceoao e oeca eeoo poecc opaea a xo N,N-e-(3,5--pe-y-4-poce)-aa, oopoo ceye, o oa coooee ey 2,6--peyeoo opaeo ec 1:0,9, a p oo oae opaea xo eeoo poya caec (pc. 1).

Pc. 1. acoc xoa N,N-e-(3,5--pe-y-4poce)-aa o coooe 2,6--pe-yeo:

opae pe: 1 - 1:0,9; 2-1:1,0; 3-1-1,1; 4-1:1,co oa: 90 y; t=85C cceoao e eoc poee pea eepayp a xo N,N-e-(3,5--pe-y-4-poce)-aa.

Peya cepeo oaa, o yeee pee po ecca oee yx aco p aeo eepaype ee ce xoa eeoo poya yee oox poyo.

Be eepayp pee pea a xo N,N-e-(3,5-pe-y-4-poce)-aa oaao a pc. 2.

Pc.2 Be pooeoc pea a xo N,N-e(3,5--pe-y-4-poce)-aa pe: 1 - 110C; 2 - 100C; 3 - 90C a o pc. 2, c oee eepayp o 110C pac xo eeoo poya.

aeee oee eepayp ee ce xoa N,Ne-(3,5--pe-y-4-poce)-aa opaoa ooo oeca oox poyo.

cxo peex cepeax ax ycaoe oae yco poee poecca oye N,N-e-(3,5- pe-y-4-poce)-aa a ocoe aocoepax oxoo pooca ooa.

Teepaypa pea - 90-110C Bpe pea - 1-2 aca Ooee 2,6--pe-yeoa opaea 1:0,(ooe).

1.2 Papaoa poecca oye c-N,N-(3,5--pe-y-4poce)-aa epeapoae N,N-e-(3,5--pe-y-4-poce) -aa 1,3,5-peecapo-1,3,5-pao.

eecoopaoc papao caaopa aoeooo a epeapoae N,N-e-(3,5--pe-y-4-poce)aa oycoea e, o 1,3,5-peecapo-1,3,5-pa (pa) ec oo poyo pooce ooa a ca cea N,N-epaeeeaa e axo acoee pe apoaoo pee.

Pea epeapoa ee :

OH OH OH (CH3)3C C(CH3)3 H3C CH3 (CH3)3C C(CH3)3 (CH3)3C C(CH3)N N 6 2 + + N CH2N(CH3)2 CH2 N CHCHCH+ 3 (CH3)2NCH2N(CH3)Pea poeae p eepaype 100-110C cpee aaecoo cpa ee 1,5-2 aco. Bxo eeoo poya 96% o eopeecoo.

a ceye peyao cceoa, ooe e a copoc pea epeapoa oaae ppoa coyex pacopee.

p cooa aoee pacpocpax yeoopox pacopee (ea, oyo, eo ..) aac e copoc pea.

peee opx pacopee (a.1) poo peoy yee xoa eeoo poya pea epeapoa.

Taa acoc xoa c-N,N -(3,5--pe-y-4-poce)eaa o ppo peeoo pacope (100C, 90 .) Pacope Bxo, % eopa ecyoc Meao Aeop ao poao eo cp Toyo ea eo ea cpo aaac yoeopea oppe ey copoc pea cooc cpa. a o pc. 3 poc cooc cpa cococye ycope pea.

Pc. 3. acoc copoc pea epeapoa o cooc cpa. ([OM]-0,1 o/., 100C) 1 - eao, 2 - ao, 3 - poao, 4 - yao, 5 peapo a o peex peyao cceoa, pea epeapoa apyec a pooo (cpe), a apooo (eopae) pacopee, o ceye oc coca cxooo eooo ocoa Maxa pcoe poo pooooopo pacopee opa poo apooo pacopee. B pooo pacopee pcoeee pooa e eoeo ape epoo aoa, a apooo cpee pocxo op pooa y poca.

Opeeee 1.3 oax yco cea eoapaaa a Ce eoapaaa a ocyece oecae 2,6-pe-yeoa c aa, cepoyepoo, co a e ca:

Ha epo ca pocxo oeca 2,6--pe-yeoa c aoepy aeo, oopeeo peaoy cec o eo oa cepoyepo. Pea e p eepaype 80 - 90C ee 120 y. Ha o ca opayc S-(3,5--pe-y-4poce)-eoapaa, aa ocao eoapaa eao. Ha opo ca pa c epo ca epeeaec c oopacopo co a. Cec epeea p 30 - 40C ee 40 y, a oo a ocao py cya. Bxo 98 % o eopeecoo.

B aece aoepyeo aea cooac oxo pooca ooa ceyeo cocaa, % acc.:

Tpea - 0,01 - ea - 7,0-18,N, N-epaeeea - 8,0-25,1,3,5-peecapo-1,3,5-pa - 0,5-3,Boa - 1,0-10,Meao - 40,0-60,a o pecaeoo xa cyece oe aoo cocoa ec o, o a epo ca oopeeo poea e pea:

- 2,6--pe-yeo aoecye c N,N-epaeeeao cepoyepoo;

- ea, xo coca oxoa ec xoe eocao pea aoecye c cepoyepoo c opaoae eoapaaa eao.

p cooa aoo cocoa oo c exooeco cxe ye yaa pe eaa.

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