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張 愼麟惟衣攸佃僚 D3-泣妊賊尿遵柚猥, 前給奧蟻診執 翟憎輦孼猥 狀循牆 壯 述鴨音杖 穽設迹 禎依淳裝 桎宜桎 菴牆赤 尿衆抑荻陝猥 脣幅 49 灑蟻裝 調孺鮑 靭怏贍茴-乙鎭調蟻狀 壯穽設音杖 惟 穽設迹 禎依淳裝 桎宜桎 孺鮑, 了 杖 櫛衰軫孼狀 牒烝歪蟻狀 喜鎖姚依燼特仲 翟前蓮薔妖 (57,1%). C釣厓僥 脣嗚葉 灑蟻裝 櫛增陝荻陝狀 穽前疾陝增橓 (レ偃適鏑佺僖桎麟) 淳 63,1 (12,7) 音. 蘭抑杖 妖鴨揄 茵葺 鎭乙 泣燼尊循杖諺 前狀純紅 泣妊荻葉有存紅 增宗揄前診淳 27 (4,6). 及楫釣鴨音杖 灑蟻裝 禎 膣 哀 茵杖艇打 全採鏑淆.

增雪 裔灑音循杖 述淳依 1 檉打孼診 Tis, 論泣 尿衆抑荻陝 檉打孼桎 I 增雪猥, 16 灑蟻裝 櫛 II 增雪猥, 驕孼魏 悚吾檉卽前震 戱輒攸外狀增 穽設- 灑蟻裝 III 增雪猥. 헥成嶢言茴策 妬增 灑蟻裝 增典佺張 愼麟惟衣攸佃僚 D3-泣妊賊尿遵柚猥 櫛增設堯 檉打孼執 愼茵桎愼牆忽 茵診增暹閃 靭怏贍茴-乙鎭調蟻狀 壯穽設音杖 音特杖 全採鏑 - 14 特依橓 (28,6%). 較菴音牆酷 靭診調魏 穽設迹 禎依淳裝 桎宜桎 孺鮑. 增暹 渟特贓 岫泣 怏說狀增寮荻陝 5 灑蟻裝 (10,2%). 膠採鏑 依魏泣吾循乙贈 衆俺迹 孺鮑 璥鎭鳥贍 靭桎液 18 灑蟻裝, 脣拯賊緘 孺鮑 23 檉打孼厥荻抑孼 釣疾前渟攸外裝 陝贍了 穽前渟攸外桎, 渟特狀杷佃 了燼悚 8. 壓採 檉打孼桎 狀 櫛訟調諺迹 凞焉疾佺狀 蓀晤 菴牆紅 剪鴨音杖 述瞬孼 穽典葉診杖 全採鏑 蓮疑裝 艇晤綜 惟依穽適桎依燼 筑宗造僚 診吾脣莘 厓 謹老 夭.

渟特贓, 診唯 桎檣策 孺鮑, 渟釣厓 鎖曝策 蟾雪. .. 躬疾荻仲謫 隙勁 裔 渟鳥賊 療 增孼有 灑蟻瀑 焌蟻杖, 竣預 特 岫乙 述 將燮 2010 娠. 宮調靭疾佃 盾誼特杖 陝贍了 禎鷹孼 釣銳柚 瘡暹陝裝 翟調吾循杖 抑妖忽 岫依 壯泣婆 燼增鏑謫料嚴孺 橓鳥淸打尊循牆迹 頌適佃 全採鏑淆.

雪孼適燮打狀荏 穽設迹 禎依淳裝 桎宜桎 孺匍釣厓僥 蓀應 鮑贍 陝嚴鎭預鏑謫料嚴惟莘 孺 (衆俺 孺鮑, 脣拯賊咸 翟賊展壯 孺鮑, 鳥仲 櫛增設堯 3,2 蓀應. 쾰嶢言茴前潗 全儼惺僚 渟特狀杷渾 昌鏑 翟賊展狀 孺鮑) 述禎鷹孼猥 櫛增設堯 157 (94) 麟腸, 汁抑 愉荻全剪儼 D3-泣妊賊尿遵柚僚. 陝贍了 診唯 岫泣 盾誼特- 281 (157) 佾. 尿衆抑荻陝狀 藎蒼渟 張 岫依 裝 鴨溢藎宬料嚴孺 禎魏裔鎭泣 灑蟻裝, 妖鴨揄 裔釣燼增鳥尊循狀 音診蟻裝 衆綵齧 30-厓億裝 茵葺 鎭乙, 菴牆酷 全採鏑億謫 裔灑音循杖, 妖汁適 禎衆 全儼惺僚.

疾攝渟調打佺裝 禎魏裔鎭泣, 筑宗造料嚴孺 前蘭抑張 惟泣特增脣 泣妊城料嚴孺 滄依, 壯雨跡張杖 音診蟻狀增 鎭特杖 30 厓彦 禎衆 鴨牆紅 穽俺燮城 24,8 (17,6), 了 杖 禎依鍊鎭蟻全儼惺僚, 菴牆酷 了 茁增諺 溢杖桎鳥帳 灑蟻裝 3,4 (2,5) 滄依. 衆綵齧 壯泣婆 N 禎調蓮杖 裝 惟依釣攸贍茴忽 調惟 剪鴨音杖 惟依穽適鏑料嚴軫 壯藕孼裝 滄依 櫛增設堯 21,1 (19,1).

攸鏑謫僚 筑宗造僚 診吾脣莘 厓 謹老 夭. 蟾雪.

蘭抑杖 汁適 莘楫嶢贍了惺僚 21 (7) 厓彦, .. 躬疾荻仲謫 隙勁. 鸞雪寮荻陝猥 裔灑音循杖 汁適 壯軸輦孼 增惺姚壯釣 禎衆 全儼惺僚 前蔡嚴軫依贈 禎 AJCC (7- 了菴杖) [6].

(5) 厓彦.

掛횻훤읫補北 喫잃湺 憾魚震純 筑宗造 佺惟依燼 較菴音牆赤 靭診增暹寮荻陝猥 禎調蓮杖諺 全尿陝裝 楫前翟 音特杖 葉櫛打寮暢秩 軸尊袍 渟特杖 岫依 翟壯宗蓮狀 1 灑蟻狀莘 渟鳥賊 482 翟緘 佺惟依燼特仲迹 述鍊循諺前潗.

厓彦 禎衆 全儼惺僚. 較靭特狀 鴨潗 音診蟻裝 爛尿適 泣鎭調膣終 尿軸哀 禎衆 全儼惺僚, 汁抑張 特釣 5,22,1. 콧述哀 .., 잴遵蟻 .. 鸞城尿震魏 依魏靭墮. 厥料妖迹 重儼震 6 灑蟻裝 禎衆槍堯 特增橓牆紅 狀脣翟調吾循杖 嗜葺僚 增調壯 穽謫釣葺 靭診增城料嚴惟莘 全採鏑億謫 穽專嚴焌 佶 2006 . // 쭤增杖 尊葺僥仲謫 佺惟依燼特竣 渟特杖 音神撓, 3 灑蟻裝 前依悅孼 蓮惟莘 壯綵狀莘 墮粧調 夭孼 . . 쥰奠妖 隙勁.

薏 遵遭円狀-櫛憎怏增紅 裔灑音循杖.

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剪菴音牆佃 渟鳥賊 穽前音蓮狀 90,1% 灑蟻2. AJCC cancer staging handbook / S.B.Edge, 裝, 汁抑杖 汁適 穽前音蓮牆前震 櫛增設堯 449,D.R.Byrd, C.C.Compton, A.G.Fritz, F.L.Greene, A.Trotti.

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.. 축莊億, .. 축訟桎循, .. 쟐膣狀循 촘 쫏 줘鮑寮仲僥 莘憎菴猝軫孼裝 靭怏打章孺 艙外儼茁鎭 축莊億 輛泣菴 輛壯淸億壯, - 靭. 壯瘡, 穽塼嚴櫛, 裔. 魏輒崖迹 純寀釣牆撓 灑音午彦 촘 쫏 줘鮑寮仲僥 췸憎菴猝軫孼裝 靭怏打章孺 艙外儼茁鎭, 450000, 給楫愴泣魏 줘鮑典桎增陝, . 導, 窓. 距杖壯, 3, 鎭./牒揄 8 (347) 272-41-73, e-mail: umu@inbox.ru 論蟻 尿衆抑荻陝 增贍 了綵孼猥 洵殲溢竣預 靭輦 張仲鏑獪夭 訟佃燮劉調麟 茁增諺狀莘 脣楫贍孼 魏仲雪佃 釣蟾打 穽謫調壹寮荻陝狀 燼悚泣 幽奄適 秧嶢言茴適債陷 灑蟻裝 春佺料嚴惟 翟增宗攸外狀 灑音午淆 音神撓 (來죄) 灑蟻裝, 夭廬陷 櫛特診牆策 檉桎依燼: 來죄 櫛 曾典麟尊循馴夭 調惟 音神謫 (菫). 尿衆抑荻陝猥 岫泣 盾誼特裝 檉打孼執-壬捻妖: 惟粧尊蟻狀 藎蒼鋌 (醴典荻酷 30 特.), 灑蟻裝 來죄 汁抑張 增俺孼 蓮增 櫛 增剡諺 有釣杖 20 音 灑蟻裝 來죄 汁抑張 增俺孼 蓮增 怏說狀烝寮荻陝裝 調惟 音神謫 櫛 增剡諺 有釣杖 25 音. 證脣尊叱 愉荻 了靭泣 惟莊孼疾惺療 CD3-CD16+, CD3+CD16+, CD4+CD25+, CD25+, CD4+95+, CD95+ 靭桎哀 穽剪展狀 打桎請典夭奄鳥 尿禎蟻吾循杖諺 溢狀幽佺贍茴紅 陝震鎭, 債荻孼 妖鎭足彦孺壯-6 (훙6) 證脣尊叱 愉荻. 찰瞬孼 憎緘增橓牆酷 檉調應言茴酷 洵殲溢竣預 墮依莘 菴 訟佃燮劉尊 茁增諺狀莘 脣楫贍孼 涉全桎裔 秧嶢言茴 有陷 泣, 夭廬陷 述調蓮牆酷 幽妖料嚴孺 穽瞬孼 來죄 魏 穽 壯泣婆 菫, 診 純 憶 幽妖料嚴惟莘 茵杖輒增. 厥抑禎乙侁奄, 破 俉前帙紅 有鳥蟻陷惟 壯泣婆諺 述櫛孺 禎魏裔鎭音 茁增諺狀莘 脣楫贍孼 裔艇仲齧秩 魏仲雪 釣蟾打 穽謫調壹寮荻陝狀 燼悚泣 幽奄適 - 涉全桎, 穽專嚴 脣 洵殲溢竣預 脣楫贍嶢言茴忽 鎚調攸儼尿震魏麟 增陝荻嶢 灑音 述調蓮牆忽.

勘特述 衆荻: 春佺料嚴魏 翟增宗攸外壯 灑音午 音神撓, 調 音神謫, 春佺料嚴孺 脣楫贍嶢言茴渾 穽專嚴, 夭壬狀依燼特仲猥 壯宗袍杖, 涉全桎.

掛횻훤읫補北 喫잃湺 憾魚震純 筑宗造 佺惟依燼 TO THE PATHOGENETIC UNITY IN THE DEVELOPMENT OF THE CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND PULMONARY CANCER Kh.Kh. Gantseva, D.M. Gabitova, S.F. Aflyatunova Bashkir State medical university Aim of researchis to study the interaction among several biomarkers of systemic inflammation and the programmed cell death cascade reactions of long smoking patients and of COPD patients with formed lung cancer.

Research included men patients: checking group (healthy donors 30 persons), COPD patients middle severity with 20 years smoking period and COPD patients middle severity with lung cancer with 25 years smoking period. In blood serum we detected the concentration of CD3-CD16+, CD3+CD16+, CD4+CD25+, CD25+, CD4+95+, CD95+ by using the flowing citofluometry method with monoclonal antibodies, phagocytes activity of neutrophils through cell capacity to absorb latex particles, the level of Il-6.

The parallel interactions among biomarkers of systemic inflammation and apoptosis of smokers with strong habit are detected. Such smokers have considerable clinical manifestations of COPD; no matter they are with lung cancer or without.

Supposed that malignant smokers with high indexes of systemic inflammation have also the reactions cascade of programmed cell death apoptosis, the process in interaction with inflammation becomes more tough.

The key words: COPD, lung cancer, chronic inflammatory process, immunological abnormalities, apoptosis.

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