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0,2. 厥 壯泣婆 贍音 G 鳥仲 調譽嶢 瑯 敞諒 124 96.12 119 99,17 1,32 0,(0,02-1,82) 泣特 3 調裔 (OR=3,072; 95% CI 1,914-4,93).

3,G 4 3,10 1 0,83 0,68 0,爛尿適 泣鎭調膣終 (0,42-34,57) 1. 宮桎依燼特仲 淸預鏑謫 / 淃 釣. ..

0,GG 1 0,78 0 0,00 0,01 0,잤 ..孔淳朶謫 杻馹, 1994. - . 283-288.

(0,99-19,08) 2. 夔惟脣愛軫 禎 愼茵桎依燼: 2- 桎茵 / 禎 0, 252 97,67 231 99,58 2,04 0,釣. ..찌尊峀億 ., 2003. . 1.

(0,02-1,48) 3. Abnormal Intracellular Level of Bax in CD3+ Cells 5,from Untreated B-Cell Chronic Lymphocytic Leukemia G 6 2,33 1 0,42 2,04 0,(0,68-47,62) Patients // Laboratory Hematology. 2006. - Vol. 12.

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腦唯 穽 陝贍了 妬增剪 愼狀震禎 禎泣溢從4. Bond G.L, Hirshfield K.M, Kirchhoff T. et al.

狀莘 依有焌 (-248) G>A 愼壯 쩜 翟壯宗蓮裝 哀MDM2 SNP309 accelerates tumor formation in a gen增荻儼裝 調俉料 禎 愼狀震艇 GG, 壯 哀誼 惟桎der-specific manner // Cancer Res. 2006. Vol. 66.

尊莘 藎蒼渟 灑蟻裝 瑯 穽撓賊堯前 74,30%, P. 10-16.

藎蒼渟 惟粧尊 46,30% (2=16,245; p=0,001) 5. Leung D.W., Cachianes G., Kuang W.-J., Goeddel (診頌擾 3).

D.V., Ferrara N. Vascular endothelial growth factor is a secreted angiogenic mitogen // Science. 1989 Vol.

腦頌擾 246. P. 1306-1309.

及楫釣鴨音杖 妬增剪 愼狀震禎 贍音6. Mathew C.C. The isolation of high molecular 音 禎泣溢從狀莘 依有焌 -248G>A 愼壯 쩜 weight eucariotic DNA // Methods in Molecular Biol藎蒼檉 灑蟻裝 瑯 醴典荻紅 妖怏淳哀 ogy / Ed. Walker J.M.. - N.Y., L.: Human Press, 1984.

- Vol. 2. - P. 31.

즈蟻裝 헉典荻酷 7. Phylogenomics of Life-Or-Death Switches in 瑯 (N=108) 2 P OR (95%CI) (N=105) Multicellular Animals: Bcl-2, BH3-Only, and BNip Families of Apoptotic Regulators / .Aouacheria, F.Brunet, 褻. % 褻. % M.Gouy // Molecular Biology and Evolution. 2005.

- Vol. 22. - 12. - P. 2395-2416.

3,GG 78 74,30 50 46,30 16,24 0,(1,879 - 5,977) 8. Ying-Fang Sun, Jyh-Der Leu, Su-Mei Chen, IFeng Lin and Yi-Jang Lee. Results based on 124 cases 0,GA 23 21,90 41 38,00 5,79 0,of breast cancer and 97 controls from Taiwan suggest (0,251 - 0,84) that the single nucleotide polymorphism (SNP309) in 0,AA 4 3,80 17 15,70 7,23 0,the MDM2 gene promoter is associated with earlier on(0,069 - 0,655) set and increased risk of breast cancer // BMC Cancer.

3, 2009. Vol. 9. P. 13.

G 179 85,20 141 65,30 21,64 0,(1,914 - 4,93) 9. Yuhui Huang, Xiaolan Chen, Mikhail M., Dikov 0,Sergey, Novitskiy V., Claudio A., Mosse, Li Yang, David A 31 14,80 75 34,70 21,64 0,(0,203 - 0,523) P. Carbone Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated 矜仲 調譽嶢 瑯 穽 壯泣婆 菴牆謫 愼狀levels of VEGF // Blood. - 2007. - July 15. Vol. 110(2).

震檉 敞言料孼 灑音 特 3 調裔 (OR=3,35; 95% P. 624631.

CI 1,88-5,98). 昆穽剪外, 愼狀震 GA 妬緘 蓴疾10. Zhang Y., Xiong Y. A p53 amino-terminal nu妬宜 藎蒼渟 惟粧尊, 特 藎蒼渟 灑蟻裝 clear export signal inhibited by DNA damage-induced 瑯 38,00% 21,90% 櫛剪橓秩軫孼狀 (2=5,79;

phosphorylation // Science. - 2001. Vol. 292 .

p=0,017). 腦唯 壯頌菴依贈 哀增荻儼狀 穽蘖1910-1915.

춧裝, 贍音泣 춧裝, 贍音泣 훌 痼當谷 价죔隙鷺瑾 憾魚震純 筑宗造 佺惟依燼 ( ) .. 축侁狀, .. 嵌猝蟾荻 輕仲荻仲僥 翟乙增狀 壯綵狀-尿衆抑荻城言劃孺 幽妖料嚴孺 妖增嶢寀 夭. .. 쯤雪夭寮仲謫 (勍苦閣) 축侁狀 距佺巍 톄愼贓億料, 魏庄. 靭. 壯瘡, 增燮鋪 壯綵裝 櫛疾昶杖 勍苦閣, 129110, 嗜葺, . 輕仲循, 窓. 懋珽妖, .61/2, 鎭.: +7 903 629 46 36, e-mail: leo-gann@mail.ru 厥抑增設音裝 釣奧蟻診執 汁設杖鎭蟻狀莘 夭壬狀燼增奠夭料嚴惟莘 了綵孼 僖楫釣葺僚 壬打狀 魏慫妖佃性 蓮懿殃, 調譽外鋪椿 魏遭歪蟻狀, 締庄贍茴佃, 陝疾贍茴佃 剪鴨乙 渟釣軸厓紅 吾壯 純 裔淳茁溢增 剪 燼增鏑謫料嚴惟莘 震檉 全採鏑.

勘特述 衆荻: 壬打裝, 魏慫妖佃 蓮懿殃, 夭壬狀燼增奠夭料嚴魏 僖楫釣葺.

MUCINS EXPRESSION BY STOMACH CARCINOMAS (COMPARATIVE IMMUNOHISTOLOGICAL ANALYSIS) L.E. Gaganov, N.A. Korsakova Vladimirsky Moscow Regional Clinical Scientific and Research Institute The results of the comparative immunohistological research of the mucins expression in the stomach carcinomas developed in forestomachs, in fundic stomach parts, in antrums and in transition zones rtegardless histologocal tumor type are represented in the article.

The key words: mucins, stomach carcinomas, immunohistological expression.

쭘抑孼猥 魏慫妖佃性 壯宗胞秩 魏 惟泣特增橓牆酷, 診 魏特增橓牆酷 禎魏裔鎭泣 僖楫釣葺僚 MUC 驚打裝 (MUC), 僖楫釣葺寮暢荏 魏慫妖佃閃, 瞬秩 循悅忽 怏說狀增料嚴孺麟 穽謫狀增料嚴- [8,10], 破 禎衆槍堯 前狀脣 秧 櫛醴陝 調俉料裝 夭壬狀輒狀震炡特仲撓 幽葉茁淸魏打, 孺麟 茵簇儼閃, 診唯 剪調縯 溢從鏑謫料嚴孺 締檣打佺贍茴酷 前翟孼狀增 全採鏑彦. MUC 剪狀- 賊壯惟 釣奧蟻診執 憙撓 尿衆抑荻陝僥 替說靭粧燮 述櫛惟溢音有存忽 紳凹全尊鎭妖閃, 禎崖暹- 裝 [1,3,5,6,7].

論蟻 壯增緘莘 尿衆抑荻陝 了綵嶢 夭壬鴨 壯 疾陝重諺鎖陝裝 遵愉奄典裝 [2].

狀燼增奠夭料嚴有 (횻) 僖楫釣葺療 MUC1, -5읾, 狀鏃 衆了尿診 翟鏑展魏 蓮懿殃 櫛鴨阻嶢 MUC1, 5읾 6 震禎, 前蔡嚴軫陷 締檣打 裔- -6 -2 魏慫妖佃性, 調譽外鋪椿 魏遭歪蟻狀, 締庄贍茴佃 陝疾贍茴佃 剪鴨乙 蓮懿殃 渟釣陷執, 釣身打 靭列音桎杷迹 雪愼預, 渟釣菴婆 軸厓紅 吾壯 靭輦 杖麟 純 裔淳茁溢增 剪 燼葺嵬壯依, 增夭窓寮策陷 夭壬牆酷 釣蟾打 [4].

桎依燼特仲謫 震檉 全採鏑.

扉楫釣葺 MUC1 壯頌菴奄 衆了尿執 幽奄魏 禎愉荻狀-溢杷謫 姬嶢言 陝疾贍茴謫 剪鴨乙, 璥鎭鳥贍 靭桎液 切魏蟻狀 姬嶢言姚打診 蓮釉 締庄贍茴謫 희衆抑荻陝 全儼惺姚牆渾 茵鎭鳥贍 55 侁增陝疾贍茴謫 剪鴨依; MUC5읾 妖鎭章外狀 述調縱攸佃僥 檉打孼桎 27-75 音, 了 杖 30 壬捻妖 蓀執循奄 切橓鏑存忽 姬嶢言猥 蓴嶪 剪鴨依;

25 蓮薔妖. 魏遭僚 依魏泣吾循依贈 11 魏慫妖佃, MUC6 穽賊砦寮暢秩 蓮音裔麟 陝疾贍茴謫 震檉, 壯 藎陝擾 魏遭僚 鎭乙 (渟釣軸厓 吾壯 I) 8, 診唯 壬惟渟綎巍裝麟 幽奄魏麟 袍円狀 吾裝 鎭音 9, 壯 藎陝擾 鎭乙 陝疾贍茴謫 剪鴨乙 (渟蓮音 陝疾贍茴謫 締庄贍茴謫 剪鴨依. 展燮嶪賊壯 吾壯 II) 10, 陝疾贍茴佃 剪鴨音 17. 鸞說性 孺袍杷迹 靭診町暹僚 禎瞬奄 僖楫釣葺 怏勖前潗: Tins 1 壯頌鴨杖, I 1, II 14, III 39.

MUC2, 狀鏃 茁粧偃寮暢溢莘 灑魏依淳厓忽 췄增鏑謫料嚴孺: 雪孼適燮打狀荏 12 壯頌鴨杖, 幽奄魏麟 孺袍杷凹.

훌 痼當谷 价죔隙鷺瑾 憾魚震純 筑宗造 佺惟依燼 雪孼適燮打狀荏 渟猝帙億巍狀幽奄展裝 惟逸- 及楫釣鴨音杖 魏慫妖佃 禎 增俺孼 夭壬狀張粧佃 22, 渟猝帙億巍狀幽奄展裝 調 20, 張- 釣蟾震純前震 穽抑增設音狀 壯 鳥. 1.

怏諦儼孼打尊循牆渾 調 1.

횻 尿衆抑荻陝猥 穽荻賊堯 尿禎蟻吾循杖諺 溢狀幽佺贍茴紅 陝震鎭 壬打壯 첥ovocastra KIT 첗AKO (invision, Mouse/Rabbit). 魏特增橓 春佃謫孼 尿禎蟻吾循泣 怏閃妖翟孼預怏 컥+ 첗AKO. 色調 幽奄適 哀愉星外贍 愼茵桎揄堯妖佃 璥虞調. 흡有蓀打 渟躁料裝麟 陝震鎭乙麟 穽荻賊堯葉 禎衆 翟調灑叱 汁偃荻 豈 釣鍊靭. 扉楫釣葺療 專孼外贍 禎 惟泣特增詢 夭壬狀釣蟾震純紅 幽奄適 壯 100 綵鎭牆紅 穽 敞言料孼僚 400. 淃 釣奧蟻診診 曾典麟尊循裝 4 藎蒼鋌: I - 衆褻 夭壬狀釣蟾震純前潗 (適調袍狀 6-25 全採鏑億紅 幽奄適), II - 脹儼孼壯 (26-50), III - 述櫛魏 (灑音 50), IV - 剪憎秩軫猥 횻 適調鋪循杖 堯 適調袍狀 1-5 幽奄適. 魏特增橓 埰依純謫 惟粧尊 矜. 1. 及楫釣鴨音杖 魏慫妖佃 禎 增俺孼 岫乙 尿禎蟻吾循壯 純蘖艇軸音循 衆了尿診 翟- 夭壬狀釣蟾震純前震 壬打壯 依把 櫛剪橓秩軫策陷 剪鴨依 蓮懿殃. 鸞城尿震特仲策 翟調灑叱 穽荻賊堯 禎汁抑增脣 檉劉診 흔依蓮牆酷 調俉料 張哀增荻儼裝 (戾-侑雪穽謫調壹 첯igmaPlot 11.0 첤icrosoft Excel. 調=12,345 穽 6d =0,055).

診頌擾 2 穽抑增設音裝 禎魏裔鎭泣 夭壬狀給奧蟻診執 翟憎輦孼猥 釣蟾震純前震 魏慫妖佃 壬打壯 裔淳茁溢增 扉楫釣葺 MUC1, -5읾, -6 -2 灑蟻鋪章軫 剪 陝城佃料嚴惟莘 剪鴨乙 ( 魏輦佃 剪鴨音 秧 全採鏑億紅 幽奄適 岫乙 怏諦滄狀 打桎町暹茵魏輦謫 了 壬打狀 綵鎭狀 禎 1000 釣穽偃孼診震蕣料嚴惟, 靭藺調牆-打桎町暹茵震特仲迹 涉妖紅 全採鏑億紅 幽奄適).

魏蟻狀 (診頌擾 1). 嵌泣特增脣 魏慫妖佃, 僖楫釣葺寮策陷 MUC1 (52 壯頌鴨杖), 哀增荻儼狀 腦頌擾 灑蟻袍 魏慫妖佃, 僖楫釣葺寮策陷 MUC5읾, -6, 羸衆 夭壬狀釣蟾震純紅 壬打壯 幽-2 (戾-侑雪調=37,645, 穽 3d <0,001). 嵌泣特增適 魏慫妖佃性 調俉料裝 陝城佃料嚴孺 軫 魏慫妖佃, 僖楫釣葺寮策陷 MUC5읾, -6, -2, 剪鴨依 蓮懿殃 穽夭儼狀 賊妖蟾荻 (28, 26 25 壯頌鴨杖 櫛較鴨薏 渟釣軸厓酷 吾裝 剪橓秩軫孼狀, 調俉料 張哀增荻儼裝). 昆夭孼- 漏 M s MUC 袍 婆衆 魏慫妖佃 僖楫釣葺寮荻贍 MUC2 (穽 陝疾- 吾壯 II 締庄- 吾壯 I 魏遭 汁設張杖 MUC5읾 -6 調俉料 張哀增荻儼裝 1* 401 551 524 546 446 494 戾-侑雪調=0,340, 穽 2d =0,844).

5AC** 222 229 7 354 116 186 腦頌擾 6*** 121 135 6 293 125 136 及楫釣鴨音杖 魏慫妖佃, 僖楫釣葺寮策陷 2**** 102 19 2 106 151 76 壬打裝 禎 陝城佃料嚴孺 剪鴨乙 蓮懿殃 戾較鴨薏 渟釣軸厓酷 吾裝 漏 侑雪調 77,3 874,6 1732,8 449,9 454,3 - M s MUC 3 d 陝疾- 吾壯 II 締庄- 吾壯 I 魏遭 <0,001 <0,001 <0,001 <0,001 <0,001 - 16 9 9 7 1 10,4 (n=17) (n=10) (n=9) (n=8) (n=11) 昆矮鏑檍 述櫛孺 禎魏裔鎭泣 壯頌菴泣贈 11 6 1 7 5읾 5,6 魏慫妖佃性 僖楫釣葺寮策陷 MUC1, 夭壬狀釣(n=17) (n=10) (n=9) (n=8) (n=11) 蟾震純前潗 岫乙 壯矮鏑孝彦 渟釣軸厓迹 吾張 II, 9 5 1 6 6 5,2 壯夭孼孝彦 陝疾贍茴佃 剪鴨音 (穽 汁設張杖 (n=17) (n=10) (n=9) (n=8) (n=11) 釣奧蟻診桎 靭輦 剪鴨乙麟 調俉料 哀增荻儼裝 9 3 1 5 (* 戾-侑雪調=71, 穽 4d <0,001)).

2 5,0 (n=17) (n=10) (n=9) (n=8) (n=11) 흠壬狀釣蟾震純前潗 魏慫妖佃 MUC5읾 戾-侑雪MUC6 岫乙 壯矮鏑孝彦 渟釣軸厓迹 吾張 I, 壯調 穽 8,607 7,673 24,000 2,011 13,162 - 夭孼孝彦 締庄贍茴佃 剪鴨音 (穽 汁設張杖 3 d 釣奧蟻診桎 靭輦 剪鴨乙麟 調俉料 哀增荻儼 0,035 0,053 <0,001 0,57 0,004 - - 裝 (** 戾-侑雪調=452, 穽 4d <0,001 *** 戾侑雪調=356, 穽 4d <0,001 櫛剪橓秩軫孼狀).

間慫妖佃 魏遭僚 締庄贍茴謫 剪鴨乙 僖蛛壹艙典魚攸外狀增 魏慫妖佃 MUC2 岫乙 穽嚴茁尊循泣 MUC1 脣 蓴嶪 衆綵. 邏茵 釣殃 壯矮鏑孝彦 魏遭僚, 剪憎秩軫荻贍 締庄贍茴佃 僖楫釣葺 MUC5읾, -6 -2 岫乙 締庄贍茴佃 剪- 剪鴨音 (穽 汁設張杖 釣奧蟻診桎 靭輦 剪鴨鴨音 (禎 1 壯頌鴨杖). 昆 藎陝擾性 剪鴨依 調俉- 乙麟 調俉料 哀增荻儼裝 (**** 戾-侑雪調=227, 婆 妬增剪 僖楫釣葺僚 岫泣 張憎緘增橓牆忽.

穽 4d <0,001).

훌 痼當谷 价죔隙鷺瑾 憾魚震純 筑宗造 佺惟依燼 昆矮鏑檍 述櫛魏 夭壬狀釣蟾震純前潗 魏慫- Motoshita, N. Oue, H. Nakayama // Japanese Cancer 狀茵, 調譽外鋪椿 壯 藎陝擾性 陝城佃料嚴孺 剪- Association. 2005. Vol. 96. 8. P. 474479.

鴨依 蓮懿殃. 희幽特杖諺 淳泣贈 魏慫妖佃, 2. Gastric Mucus Alterations Associated With 僖楫釣葺寮策陷 MUC2, 禎魏裔鎭泣, 夭壬狀釣蟾- Murine Helicobacter Infection / J.M. Schmitz, C.G.

震純前震 惟桎終 渟釣軸厓紅 吾壯 I II 岫泣 杖蓮, Durham, S.B. Ho, R.G. Lorenz // J. Histochem. Cyto特 魏遭僚 陝疾贍茴佃 剪鴨音. 卵抑暢 剪靭震潗, chem. 2009. Vol. 57. 5. P. 457-467.

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- .. 톈典荻, .. 쥔足荻, .. 煤陰, .. 쭌茁, .. 췻昶妖妖 躬鎭趙債蜃孺 妖增嶢寀 鴨存迹 淸預孺 隙, 剪鴨音杖 溢音有存迹 調怏惺姚牆迹 訟塼了凹 昆綵狀-尿衆抑荻城言劃孺 妖增嶢寀 藎寥檉 珞橓尊-행檉厓謫 剪鴨音杖 隙勁 昆綵狀-尿衆抑荻城言劃孺 妖增嶢寀 僖楫儼夭孼診蟻狀 靭怏打裝 珞橓尊-행檉厓謫 剪鴨音杖 隙勁 톈典荻 쯤雪夭寮 쭌音綜億料, 魏庄. 訟鏑. 壯瘡, 增燮鋪 壯綵裝 櫛疾昶杖 苦 藎寥檉 饑 隙勁, 197376, 嗜葺, . 邏檣-躬鎭趙債, 窓. 厥塼. 淃禎循, 15/17, 鎭.: +7 921 780 37 06, e-mail: toizeg@gmail.com 厥抑增設音裝 釣奧蟻診執 僖楫儼夭孼桎 禎 禎懿特杖 in vitro 惟逸音揄荻 展樂孼狀莘 贍橫-乙攸贍恢脹妖 特依橓魏 鏑堰狀脣 孺衆剪, 禎鎭莊歪蟻狀 楫前翟裝 雪釣卽佃 脣醴彦增淳 壯 幽奄孺 全採鏑彦.

勘特述 衆荻: 贍橫-乙攸贍恢脹妖, 鏑堰狀循 孺衆剪, 壬蟻震靭存酷 惟逸音揄, 穽剪外傳艇軸音循 蟾震純前潗.

훌 痼當谷 价죔隙鷺瑾 憾魚震純 筑宗造 佺惟依燼 HUMAN ALPHA-LACTALBUMIN AND OLEIC ACID COMPLEX PREPARATION V.V. Egorov, M.N. Berlov, A.A. Shaljan, A.V. Vasin, N.A. Grudinina St.Petersburg Institute of Nuclear Physics of Academy of Sciences of Russia Influenza Research Institute of the North West Branch of Academy of Sciences of Russia Environmental Medicine Research Institute The article states the trials succession results of purified human alfa-lactalbumin in vitro complexes and oleic acid which are potentially able to targeted action to tumor cells.

The key words: alfa-lactalbumin, oleic acid, multimeric complexes,anticancer activity.

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