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aea XVIII: X1=X2=CH3, XIX: X1= CHN COOCH2CF3, X2=CH3; XX: X1= CH3, X1, XSO2 NH CO NH X2=OCHN X1 Xaoa cpyypa XVII: X1= Cl, X2= SH;

- yaa eca aoee aopo oa, coeeo o epo aoc ococ, poyoo eca, opoae ao cpyype;

- pae, oa oopx eeaea c o ococ;

- aea eeaea o epo aoc oox ce N=C.

Xaea XXII-XXIV: X1= OCH3, XXII:

N X2= OCH3, X3= OCH3; XXIII: X2= SO2 NH CO NH X1, X2, XN OCH2CF3, X3= OCH(C2H5)(C3H7); XXIV:

X1 XX2= CH3, X3= CH3; XXV, XXVI:

X1=OCH2CF3, X2=OCH3; XXV:

aoa cpyypa XXI: X1= X2= X3=OCH3; XXVI: X3=Cl X3= Cl Mecma, eaonpume ae c nouu epuuo amuocmu u mocuocmu, maue e, a npueeo e opy.

Cxea 3. Cpyyp, ceeppoae c yeo epo aoc ocpo ococ 50.

cooae p ae cycpyyp, ex pax accax xecx coee pao oapaeoc c pa exao ec, oe cyeceo ye x eoc pacp cep ec. Coee (XXVIII, XXX) ceeppoa a ocoe cceyeoo acca ocoepax coee acca poox ocoox co, coee (XXXI, XXXII) a ocoe cyooe aoco, cxea 4.

(XXIX), (XXX) (XXVII), (XXVIII) Oopeea aea R= S* a -O-**, a Oopeea aea R= NH* a -O-**, R1 = Cl* a CH2P(O)(OH)2 ** aoo cpyype a R1 =OH* a CH2P(O)(OH)2 ** aoo cpy(XXIX) po opaoa coee ype (XXVII) po opaoa coe(XXX) e (XXVIII) pueaue: upa ooo paema ooaaem oepeocm ae;

R cycmpymyp, eee ucceyeo acce uuocoepaux coeueu, R1 - acce npouox ocoox ucom Cl CH H C (CH ) COO N H CO F CH SO NH CO NH N SO NH CO N Cl HN N CH CH O CH OCH Cl COOCH B A BA (XXXI) (XXXII) acm A - cycmpymyp, ee acce npouox -auoucom; acm B cyouoeu.

Cxea 4. Cpyyp, ceeppoae a ocoe cycpyyp, eex ecox accax coee eecoopaoc opepo p ae a oepeoc ae oecee oe cceoa oepea cooecy oa c opaoae a ax, a eax cpyyp, cxea 5.

16. 15.

O CH OCH14. N 4. N 4.

7. 11.

6. 1.

SO NH CO NH N 3.

SO2 NH CO NH N 2. 14.

14.

N N 5. 9. 15.

4.

S CH3 CHO CH CH aoa cpyypa I (XXXIII) 15. 14.

O CH13.

N 5. 5.

10.

6. 3. 7.

2.

8 -SO2 NH CO NH 11. N 4. 12.

8. SO NH CO N C H OH 13.

N 1.

COCH(CH ) Cl CH9.

Cl aoa cpyypa (XXXIV) (XXXV) Cxea 5. Oea oooc opaoa ax eax cpyyp cooec c pace eea aox cpyyp Maa oa cpyyp (I) ye ae paea (oepeoc 5-a 16), epoee ceo oa pec opaoa ao cpyyp (XXXIII). aea e cycpyyp coee (XXXIV), oopa o pace a e oe oa (oepeoc 8-15, .e. c y paea), oa pec eao cpyype (XXXV), cxea 5.

Aao ye, a a cxee 5, ceeppoa cpyyp (XXXVII-XLIV), eoope x c yeo cepoo e, caoo o c opo aox cpyyp, o c opo aoaeex paeo.

X-SO2-NH-CO-Y-Z (XXXVI - XLIV) (XXXVI): X= - 3-C6H4CF3; (XXXVII, XXXVIII, XLI-XLIV): X= - 2,5 C6H3(CH3)2;

(XXXIX): X= Cl; (XL): X= -2-C6H4Cl; (XXXVI-XXXVIII, XL, XLIII, XLIV): Y= NH;

(XXXIX): Y= N-CH(CH3)(COOC2H5); (XLI): Y= N-CO-CH(CH3)2; (XLII): Y= ;

(XXXVI, XXXVII, XL): Z= - 4,6-: ; (XXXVI, XXXVII): 4-CH3; (XL): 4-NH2;

(XXXVI): 6-OCH3, (XXXVII): 6-OH; (XL): 6-CH; (XLIII, XLIV): Z= - 4,6-T: ;

(XLIII): 4-OCH3, (XLIV): 4-CH3; (XLIII, XLIV): 6-OCH3; (XXXVIII): Z= ;

(XXXIX): Z= -3,4-C6H3(Cl)2; (XLI): Z= C2H4OH; (XLII): Z=0.

Ceye oepy, o poep oppeoc apae eeapaeoo cea ceeppoa e oo ae, o eae coee; poo x aoc ae coaae.

7. poocece cepeae oe ceeppoax coee ceeppoax coee apy c aoc poopoa ae pa aoc. Haoee coe pa e coee VIII-X, XII, XIII. Coee XVI, XVIII, XX, XXXII, XXXIII, XXXV-XLIV cepoa, x epa aoc poepea cepee, a. 5.

Taa 5 - epa aoc eoopx coee, cepoax cooec c peyaa aa pooa ae o aoc Cooece ax poHoep Coeee oa cepea cpyyp poo cepe 1. XVI A* e ax 2. XVIII** B* 3*** +**** 3. XX A 100 /a + 4. XXXII B 4,0 -**** 5. XXXIII A 100 /a + 6. XXXV B 3,0 + 7. XXXVI A 4,0 + 8. XXXVII A 4,0 + 9. XXXVIII B 5,0 - 10. XXXIX B 5,0 - 11. XL B 4,0 - 12. XLI B 2,0 + 13. XLII B 3,0 + 14. XLIII A 5,0 + 15. XLIV A 25-33 /a + pueau: *- A - coeueue amuo, B coeueue eamuo; **- (XVIII) npooupoao onoumeo a peymop pocma, ma amuocm nomepea cnepueme; *** - ae aopamopoo cpuua ( aax); ****- + npooupyee u cnepuemae ae conaam, - e conaam.

Cooece peyao pooa cepea cocae 70%. Coeee XLIV yceo poo cep pacpex ca.

8. poo ococ ceeppoax coee o poo oea ococ ce coee oece accy yepeo aoocx (50 oee 150 /), a. 6.

Taa 6 - Oea ocpo ococ coee, cepoax cooec c peyaa aa pooa Pacee ae Coeee Tococ, / 1 X, XI, XXXIII, XXXVI, XL, XLIV 501-2 XXXII 1500-3 XX, XXX 1800-4 XXVIII 2300-5 VII, XXXVII 3000-6 XXXIX 4501-7 VI, VIII, IX, XII-XVI, XVIII, XIX, XXII-XXVI, >XXXI, XXXVIII, XLIII pex coee ec cepeae ae o ococ XVIII (50 pc >5000 /), XX (50 1446-2500 /), XLIV (50 1100 /), a. 6.

C o pe oaoo coea poopyex coc (coa epa aoc - pace pa 1 a ococ 50 >5000 /) aoee epce c cocpypoae coee 2-[(4,6- eocp-2-) oc] -4- (eoco) 5- e eoo co eo p;

2-[(4,6- eocp-2-) oc] - 4- e - 5- (eoco) eoo co eo p (coee VIII, IX, cooeceo) eepoece aao (coee XII, XIII).

BBO 1. poox ao- ocoepax eepoecx coee eoa oepo x pacoaa opao e acoc, cae x cpoee, epy aoc ococ, oope peaoa o, o:

S opeee oece xapaep ocpyyp a epy aoc ococ;

S e oec cpyypx apaepo (pea aop pao), xapaepyx epy aoc cceyex coee;

S ycaoeo, o eoope pae (CH2het-O-C=C, SO2-N-C=C; NH2-N-SO2, C=O-N-NH2; O-N=C-CH2het p.) oaa ooapaeoe ece a epy aoc ocece coca.

2. Papaoa aeaece oe pooa epo aoc, oaae xopoy coacoaoc poopyex cepeax ax (o 70 o 92 % a pax cepx coee), oope cooa pooa epo aoc.

3. Opeee apae aa eeapaeoo cea epcex aoocx epo a ocoe ao- ocoepax eepoecx coee. p o ycaoeo, o oe eee oye ax coee, oopa oe coacyec c eee oa o ococ, ec oa cpyyp, coepax aoce eepo, oopx peaaec aea aoa oopoa p eepoaoe (apep, p aopye, cao c SO2, pocpye p.), aoa Cl; aea aecee poo e (Cl, SH OH).

4. Ocyeceo ocpypoae oeao-ax cpyyp; oye pooe oe aoc ococ. o pace a ycaoeo, o cocpypoax coee o oea cooyoc epo aoc ococ aoee epce c 2-[(4,6- eocp-2-) oc] -4- (eoco) 5 -e eoo co eo p; 2-[(4,6- eocp-2-) oc] - 4-e - 5- (eoco) eoo co eo p (coee VIII, IX, cooeceo) eepoece aao (coee XII, XIII).

5. 14 coee oye cepeae ae o epo aoc. Cooece poopyex cepeax ax cocae 70%. Coeee XLIV yceo poo cep pacpex ca, ococ eo cooecye poopyeo.

6. Coppoa oepe aa ax aa a, coepae cee o paeo a epy aoc ococ, xapaepc apae oa oe pooa ao- ocoepax eepoecx coee, eoxoe aa pooo oe ox coee.

CCO PAOT, OOBAHHX O TEME CCEPTA 1. apoa .C., Tpa .A., xaoa B.T. Oea cpyypx pao N-,S-,O- coepax eepoecx coee a poee epx coc//Cop ayx cae pecyaco ayo-paeco oepe oox yex Mooe yee ooy cee. - a, 2000. - C.173-175.

2. apoa .C., xaoa B.T., Tpa .A., Bao P.., Coooa T.C., ayxaeoa P.X. poo op apae cea epo-ax eepoecx poox//Cop ayx pyo X Bcepoccco ayo oepe Hoe oce x apox eepoecx coee. - Capao, 2000. - C. 83-84.

3. apoa .C., Tpa .A. oc ox ecx peapao a ocoe yeoopooo cp//Te. oao II- o Meyapooo coya Haya exoo yeoopox cepcx cce 2000. - a, 2000. - C. 125.

4. pa B.B., Tpa .A., pa A.B., apoa .C. Papaoa oepo cce pooa epax ae ococ xecx coee//Tec oao XIII Meyapoo ayo-execo oepe Xece pea, peae poecc aooao x. - Tya, 2000. - C. 232.

5. Tpa .A., apoa .C., Coooa T.C., Bao P.., ayxaeoa P.X., xaoa B.T. apaoop a peya Sar pyaoo cpa ox ooec-ax cpyyp//Tpy eyapoo ayo-execo oepe Copeee opaoe exoo. - ea, 2000. - C. 95.

6. yaoa A.., o A.M., Tpa .A., Coooa T.C., ayxaeoa P.X., apoa A.C., apoa .C. oep poo oeyp a oeax epo acca ocapoox co//Te. oao II Bcepoc. ay.-ex. o. oepe exoo aye, poepoa, pooce. - H Hoopo, 2000. -ac XI.- C. 16.

7. apoa .C., Tpa .A., o A.M., Coooa T.C., xaoa B.T., aaeea .. Cpyype peoc epo aoc eepoecx poox cyooe, oeyp a epo- ax coee//Te. oao 1-o eyapoo oepe X ooeca aoc aocx eepoo aaoo. - Moca, 2001. - C. 132.

8. apoa .C., pa A.B., pa C.A., Tpa .A. oepoe oepoae c cpyypa-ooecoe ece eoopx acco eepoecx coee//Maepa eyapoo ayo-paeco oepe Moepoae. Teop, eo cpeca. - Hooepacc, 2001. - C. 35.

9. yaoa A.., pa A.B., pa C.A., apoa .C., Tpa .A. Hapae oa coee acca ocaaapoox co//Maepa 52- ayo-execo oepe cyeo, acpao oox yex. - a, 2001. - C.29.

10. pa A.B., apoa .C., pa C.A., Tpa .A. poo oeca ooecx coc N-,S-,O- coepax eepoecx coee//Maepa 52- ayo-execo oepe cyeo, acpao oox yex. - a, 2001. - C. 33.

11. pa A.B., pa C.A., Tpa O.B., pa B.B., apoa .C., Xay .A., Tpa .A., yapae T.P., aop E.A., Bao P.., Hypea..

Cpyype xapaepc ococ poox aoo, ee eoo SAR//apc xec ypa. - 2000. - T 7.- 5.- C.32-33.

12. Tpa .A., apoa .C., pa A.B., pa C.A., yaoa A.., aaeea .P., xaoa B.T., Bao P.., ao A.M. Be cpoe eoopx eepoecx coee a x epy aoc ococ//Apox. - 2002. - 3.- C.35-41.

13. Tpa .A., yaoa A.., pa C.A., pa A.B., apoa .C., Xeoa T.., aop E.A. Moeyp a oeax epo a ocoe poox oc-aaapoox co//Apox. - 2002. -4.- C.65-69.

14. pa A.B., yaoa A.., pa C.A., apoa .C., pa B.B., Tpa .A., B.C. Cpyype peoc ooecx coc eepoecx coee//oa II Meyapoo ayo-paeco oepe oepe exoo aye, pooce, coax ooecx poeccax. - Hooepacc, 2001. - C. 51.

15. apoa .C., pa A.B., xaoa B.T., pa C.A., Tp A.A., o A.M., Tpa .A. pooe oe a oe cceoa c cpyypa-ooeca aoc-ococ. Cpyyp aa oec poo oeax epo-ax coee//apc xec ypa. - 2002. - T 9.- 1.- C. 33-38.

16. pa A.B., Ayxaeoa . C. (apoa), pa C.A., xaoa B.T., Tp A.A., aop E.A., Tpa .A. pooe oe a oe cceoa c cpyypa - ooeca aoc - ococ ac 1. Opeeee apae eeapaeoo cea oeao epcex eco//ec yo. X xeca exoo. - 2002. - T.45, . 5. C. 132-139.

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