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Ha paax pyoc AMXAMETOBA PA CAHAXMETOBHA MOEPH AH POHO OOECO ATBHOCT AMO- MHOCOEPAX ETEPOECX COEHEH Ceaoc 02.00.03 Opaeca x ABTOPEEPAT ccepa a cocae yeo cee aaa xecx ay a 2002 Paoa oea co ocyapceo eo execo yepcee Hayo-cceoaeco exooeco cye epo peyopo poca pace Aae Hay Pecy aopoca Hay pyooe oop xecx ay, poeccop Tpa Apaea.

Oae ooe: oop xecx ay, oe Maoa A apaoa;

aa xecx ay, cap ay copy peea Mapapa Cepeea.

Beyee pepe apc ocyapce yepce.

aa cococ 27 eap 2002 . 15 aco a acea ccepaooo coea 212.289.01 p co ocyapceo eo execo yepcee o apecy: 450062, Pecya aopoca, . a, y. ocoao, 1 C ccepae oo oaoc oee HT.

Aopeepa paoca 27 op 2002 .

e cepeap ccepaooo coea A.M. Cp 3 OA XAPATEPCTA PAOT Ayaoc pao. Paoopae ao- ocoepae eepoece coee axo peee aece eco, eapcex cpec pyx ooec ax coee. o ooe paccapa x a o oox epcex acco coee pacpe accopea cpec xeco a pace. ae acoce, cax cpoee x ooecoe ece, ooe pecaa coca xecx coee poo eepa a cpyyp c aa oeco xapaepc (apep, aoc ocooece coca). B peyae cyece opao cac apa a ca oca ox coee. ooy cceoa, pooe o apae, eycoo aya epce.

e pao. cceoae acoc ey cpoee ooeco aoc ao- ocoepax eepoecx coee, oeyp a poo coee c a oeco ooecx coc, a epa aoc a ococ.

B cooec c ocae pee ceye aa peeo accy ao- ocoepax eepoecx coee:

1) cceoae cpyypx apaepo a oec ooecx coc: epy aoc ococ;

2) papaoa, aa apoa aeaecx oee pacoaa pooa;

3) opeeee apae aa eeapaeoo cea (op aox coee ee x eeo cpoe, oeax oa);

4) a poo epcex epo c yo x ococ.

Haya oa. Bepe e eopeece aooepoc, cae cpoee ao- ocoepax eepoecx coee c oeco ooecx coc, aaec o, o:

- pacca oecee a paeo oey poee aoc;

- coppoa aeaece oe pooa epo aoc.

Bepe opeee epcee apae eeapaeoo cea ox epo-ax ao- ocoepax eepoecx coee, oope aac o, o:

- pace y e cpyyp x yoae py, oa oopx aoee peoe;

- e cpyype xapaepc, eee oopx cpyypy cepyex coee, po oaoy coea aoc ococ.

paeca eoc pao aaec o, o peyae cceoa e ao- ocoepae eepoece coee, peoee oa, aeee oe yoae py, o ec ocoo eeapaeoo cea ox epo. Coppoa oepe aa ax aa a, coepae cee o paeo a oec coc: epy aoc ococ. Coppoa oe pooa, peoe xapaepc apae oa.

Peya cceoa coyc p eeapaeo cee epcex epo-ax coee HTe AH P, ocooeco ecpoa a aepe e M, opaoaeo poecce a aepe eoacoc pooca pao oo HT.

Apoa pao. Ocoe ooe peya ccepaoo pao oaac ocyac a II Bcepoccco ayo-execo oepe oepe exoo aye, poepoa pooce (. H Hoopo, 2000 .); Meyapoo ayo-execo oepe Copeee opaoe exoo (. ea, 2000 .); X Bcepoccco ayo oepe Hoe oce x apox eepoecx coee (. Capao, 2000 .); Pecyaco ayo-paeco oepe oox yex Mooe yee ooy cee (. a, 2000 .); II Meyapoo coye Haya exoo yeoopox cepcx cce - 2000, oceo 10-e p eapa o cyepeee Pecy aopoca (. a, .); XIII Meyapoo ayo-execo oepe Xece pea, peae poecc aooao x (. Tya, 2000 .); 1- eyapoo oepe X ooeca aoc aocx eepoo aaoo (.

Moca, 2001 .); Meyapoo ayo-paeco oepe Moepoae.

Teop, eo cpeca (. Hooepacc, 2001 .); 52- ayo-execo oepe cyeo, acpao oox yex HT (. a, 2001 .); II Meyapoo ayo-paeco oepe oepe exoo aye, pooce, coax ooecx poeccax (. Hooepacc, 2001 .).

ya. o ee ccepa oyoao 6 cae 11 eco oao.

Cpyypa o ccepa. ccepaoa paoa coco ee, oopa epayp, ocye peyao, oo poe. Maepa oe a 149 cpaax eca coep 15 a, 28 pcyo, a ae poe a cpaax. Cco epayp ae 138 cco a ya oeecex apyex aopo.

COEPAHE PAOT Bo ee oocoaa ayaoc pao ee paeca aoc, opeee e aa cceoa.

B epo ae (oope epayp) oca ooece coca ao- ocoepax eepoecx coee, poaapoa ece acoc ey cpoee epo aoc eepoecx coee, ocye eo e aooepoce, eo pooa coc oeypoo aa oeao-ax coee.

Bo opo ae pecae peya ocyee cocex cceoa.

B pee ae peeo ocae ocox eo poee eopeecx oepx cceoa e aoc cpyypa - aoc.

1. Meo cceoa cceoa c "cpyypa - coca" oe c oo oepo cce "SARD". poopoae o ccee pooc c cooae aeaecx eoo eop pacoaa opao a ocoe cpyypx oeypx opy. Ccea ae aaec o, oop peaae oe paeo coee, oppoa oee o oeypoo aa oeao ax cpyyp.

Bce cceyee coee opaee a acc oye, coepa oey c ec coca, poopyey pyy oey. Aapye acc oye o cceyeoy cocy pae a e aepae py (ae eae). Coae oe peca ypae oecoo a: A = F (S ), e A aoc, (S) pea aop pao (PH) oec paeo cpyypx opy pax x oa, a aaex cycpyypx ecpopo. Oea paeo x coea a aoc pooc a ocoa oea opaoc, eeoc peeax o yc 1 o c 1. e e acooe aee opaoc, e e epooc aoo paa a coca. a c xapaepye ooeoe e, yc - opaeoe. F - aop, c oo oopoo ocyecec pacoaae coc cceyex eec. B poecce pooa coyc a aopa eoep (I) oocoae (II). ep x ocoa a opeee pacco eoo epe ey cceye eeco pac oeec aoo cceyeoo coca. Bopo eo peycapae aa ca pao (ooco) cpyype coee, c ooeo opaeo opaoc. poeyp oeypoo aa oca aee paee 5.

2. Be cpyypx paeo ao- ocoepax eepoecx coee a epy aoc cceoa c cpyypa-aoc poee a accax coee, ax ooo 350 poox ao- ocoepax eepoecx coee. oe aeoc peyao a x ocoe coppoa p oe pooa aoc (M1-M3), oope oac pep oppoa aepax py.

Heoxo ao oppoa oee aa ec oea pao a cceyey aoc. B poecce cceoa oe cooc ceeppoao oeeo e (opaoc) ooo oa pax paeo x coea (coe pae: o ).

Beo, o oa apaeoc xapaepa (ooeoe opaeoe) aoee ax cpyypx paeo a epy aoc o ce pe oe coxpaec, pc. 1.

o ecx paeo x , yaae apae N N N N N N S N 108 150 140 102 192 122 121 Pc. 1. Be paeo ao- ocoepax coee a epy aoc yoca eppea e cex paeo a epy aoc paccopeo c yo x paeoc pa yoa pya. ocoy oe M1 ec aoee oe, coppoao a ocoe oeeoo, cpyypo paopooo pa coee, o oee opo aa poee paax o oe.

2.1. Be ecx paeo Ao cepocoepae . Haoee co ooe a poee aoc oc 2, 4, 6 a. nupuuu cu-mpuauu (o 108 150, pc. 1). p o o opay oee cooopae coe pae: apep, nupuuu - c aoo ucopoa emuo pyo (opaoc, r=0,439), a cu-mpuauu c aoa aoa ucopoa (r=0,209). ax opaex pao y x paeo e eo.

Tae aee ooee a oc pae: 2, 3 - 2, 3, 5 a. nupuu (A, B, pc. 2); 1, 4, 5 a. nupaou (C), pc. 2.

N S N O N S N N N N N A B C D E F Pc. 2. eepoece pae, ec cycpyyp paea Opaeoe e oaa nupuauu (D); 2, 5- a. muauaou (o 140, pc. 1); 2- 2,6- a. eomuaou (E, F) x coea c py paea, pc. 2.

ecee apoaece apo. Haoee ooeoe e oaae 1, 2, 4, 5 Ar. Tae ece pae a Ph, 1, 2, 4 Ar, 1, 3 1, 4 Ar e eyco xapaep , oop cyeceo ac o opex aecee. Ta eee copoa 4-oe ooee ee xapaep 1, 2, 4 - Ar c opaeoo a ooe. To e caoe xapaepo paea 1, 4 - Ar.

2.2. Be aecx paeo Aocoepae pae. Hao ooe a xapaepe py N=C u N. Macaoo aa pae N=C ocae coea c C=C pyo ucopoo. Coea N c N=C, CH3, ucopoo cu.mpuauuo ooe; c Ph, C=O, CH3, paeo CH2het (CH2, coee c eepoaoo) - opae.

pya NH2 ee cao opaey opaoc. Ho e coea c pya C=C u C=O ooeo a aoc, oa a c N=C paeo muauaouo opaeo.

py NH NO2 oaa opaeoe e; pya NH pax coeax ee a ooeoe, a opaeoe; ooex pao y py NO2 e oeeo.

Cepocoepae pae. Ba py SO2 opaee, o eec p pax coeax c py paea: c NH pyo, C=C Cl opaye opaee pa; c N=C, C=O 1, 2-Ar - ooee. paeo S, C=S xapaepo opaeoe e, oopoe oe eppoa a ooeoe. Ta coea cep c CH3 CH2het e ooey opaoc, c pya NH C=O - opaey.

copocoepae pae. Ocupynna ee coea: c 2, 4, 6 a. nupuuuo, 2, 3-ua. nupuuo, paea N=C CH2het, CH3 pyo oaa aeoe ooeoe e. ax opaex pao c ocupynno ooe e eo. apoua u upocupy xapaepyc ooe e a aoc. Ho x a eyco eec acoc o paeapoo opye.

aocoepae pae. mop coeax c C=C pyo ee po pae ooe xapaep. Xop oc eoop opae a poee aoc, apep, coea c 2-a. eomuaouo.

3. Be cpyypx paeo a oec coc, a epy aoc ococ ooecx ca oceyeo pee cocpypoax poopoax coee oe ao o a oceeco ca p ae ox cpyyp, o oooc yec e oo aoc, o ococ. C o e poe oec aa paeo a oa x coc.

o xapaepy pae, cae oopeeo c epo aoc ococ, oo opae a ceye py:

1) pae, ycoo cae c epo aoc o ococ: 2, 4, 6-a. nupuuu; 1, 2, 4, 5-Ar, mop;

2) pae, oaae eooaoe e a epy aoc ococ acoc o coea c py paa:

- pae, oope cococy poe epo aoc oopeeo a) ca c o ococ: SO2 pya coeax c pya C=O, C=C 1, 2 Ar; pae CH2het coea c C=C C=O pya; cu-mpuauu, ocoeo c ucopoo, pya N CH3;

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