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BulletinofMedicalInternetConferences(ISSN22246150) 598 2012.Volume2.Issue8 ID:201208213A1545 ..,..,..*,..* ӠΠӠ..., *ӠȠ 450. 450. . :,,. ,, . 堖 ,. , ,. , . ().(), . 450 ,, ().4502C9(CYP2C9) ࠖ, XP3174.,CYP2C9*2CYP2C9*3(廠 ) CYP2C9[1]. ., SILVHIAѠ [2]. . : (AGT),(REN),III2(AGTR1,AGTR2), 45029(CYP2C9). ʠ30à,. 48,18,2,6,93,6.Ġ12 àʠ2008.:堖169,672,04..,堖93,51,8.. àĠ.. .50.1 . ʠ, M.B.Johns.[3]. . ...͠ʠ ., ,., ,. ,. . (Πﻠ.). www.medconfer.comBulletinofMedicalInternetConferences,(ISSN22246150) 2012.2.ʠàࠫ, ,Ġ[4]. "MicrosoftExcel2003""Biostatistics"Windows(4.03). (G83A)REN6(20%),GGࠖ16 (53,3%),G8(26,7%).,Ѡ(235)AGT14(46,6%),12(40%)4(13,4%) ,.,,AGTR12(6,7%),20(66,7%)8(26,6%),., ,AGTR27(23,3%),13(43,4%)10(33,3%),. CYP2C9:廠9 (30%),Ҡ(C430T)5,Ѡ(A1075C)4. 컠(CYP2C9*2CYP2C9*3). REN AGTR1.Ӡ(G83A)RENĠ()3,2..., Ġ()3,8...ӠGGGA(G83A)Ġ 14,4...,Ġ18,6...Ӡ,Ѡ(1166)AGTR1 Ġ5,8...21,7...,Ġ3,7...18,2....Ӡ AGTAGTR2 ĠĠ.Ҡ(430)CYP2C9 ,ĠĠ4,2...5,9...,Ѡ (430)CYP2C9ĠĠ19,6...21,5.... Ѡ(1075)CYP2C9(Ġ4,1....Ġ3,2 ...),(Ġ16,1...,Ġ17,2...)(). . ,.,.. 6:(3,2),GG+GA(14,4)* RENG83A GG+GA24:(3,8),GG+GA(18,6)* 4:Ѡ(5,6),+Ѡ(6,1) AGTT235C +26:Ѡ(4,7),+Ѡ(8,7) 2:Ѡ(5,8),AC+(21,7) AGTR1A1166C AC+28:Ѡ(3,7),AC+(18,2) 7:(10,1),+Ѡ(11,8) AGTR2C3123A +23:(11,2),+Ѡ(12,1) CYP2C9*25:Ҡ(+4,2),Ѡ(19,6) (C430T)25:Ҡ(+5,9),Ѡ(21,5) CYP2C9 CYP2C9*34:Ѡ(4,1),(16,1)* (A1075C)26:Ѡ(3,2),(17,2)* :*p<0,05. 堫ĻĠ(Ġ ). , à(AGT),(REN), III2(AGTR1,AGTR2),45029(CYP2C9),, . REN,AGT,AGTR1,AGTR2CYP2C9.,à AGTAGTR2.Ӡ, ,Ġ. ӠRENAGTR1 .,(G83A)REN (p<0,05),GGGA. (A1166C)AGTR1: Ѡ,ѠA( ). ,AGTR1 ,򠖠. ,à . [ ,2012.www.medconfer.com BulletinofMedicalInternetConferences(ISSN22246150) 600 2012.Volume2.Issue8 ӠCYP2C9(CYP2C9*2CYP2C9*3) .Ҡ(430)(5)7, .Ӡ,Ѡ(1075)(4 ),. ,CYP2C9*2CYP2C9*3 EXP3174CYP2C9[1].Ӡ ,. 235Ѡ3123AGT AGTR2.REN,ѠAGTR1 .CYP2C9*2CYP2C9*3 ., ,450, . 1. YasarU.,ForslundBergengrenC.,TybringG.etal.PharmacokineticsoflosartananditsmetaboliteE3174inrelationtotheCYP2C9genotype//Clin. Pharmacol.Ther.2002.Vol.71.P.8998. 2. LiljedahlU.,KarissonJ.,MelhusH.,KurlandL.,LinderssonM.etal.Amicroarrayminisequencingsystemforpharmacogeneticprofilingof antihypertensivedrugresponse//Pharmacogenetics.2003.Vol.13.P.717. 3. ... 4. JohnsM.B.,PaulusThomasJ.E.PurificationofhumangenomicDNAfromwholebloodusingproteinaseKtreatmentfollowedbyphenolchlorophorm extraction//AnalBiochem.1989.Vol.180.P.276278. 5.



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