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a epo oee e pex ece, poex co pee op oo e, ox c yex coee oopa aoee ee, cocoe peopa e ox, oepyx oye cepex oax.

poea xeco pooyeo a eco papaaaec aopaopx ceo pa, oe ycex o oac ocy ae cpae.

paecoe peee poeopo, oao, aaaec a p pyoce, cax a c ocoeoc coyex coee, a c aoceoc cee o x ec pax ycox oye.

MEXAHM POTBOEBO AT p aae pooyeo a eocx opao oo cxo peoaaex exao a eo, ocoy, a ye o oaao, ocoe cpo ocpo yeo oe oycoe e eo pecx cce opaa. B oocex paoax, ocex aoy ey paoopax xecx eec, aop epoaao cpec pacpoa oeype oxece exa a, cee cceyex poeopo. -a ooopa cooc ocpoo yeoo cpoa aaoc aoepo cyecoae yepcaoo exaa a. Oao o epe aoe cepeax ax ce oee pea caooc pecaee o oe exaue ecmu ec e acoo cex, o o pae epe pox acco ax eec. O o ceecy oocee oe eoeooece pa aoo ea cax paoopax poeopo. pee ceo x po eoxooc ee poeopo o oye. aoee ex poeopo x cece, a ae oc o pep aeoc ox cepeax a eax i vitro pepo oao, o cocae ~ 34. O coco cex poeopo oc ec acoc x ec o eoc a c yeee oceeo yeaec ceae.

Ec cxo cxoca poe aoo ea cea o o cyecoa oeo exaa a, o oae c o eocpeceo yac poeopo ae a, opeeeo o ( cex acco eec coco). C a e ocoae oo peoaa, o paoa e oycoe ooapae eaoec ee, acya o e pax pooyex aeo eaco o x ppo. eo oy coc oe, ocypye ae eoo oocpeoaoo exaa a. x pae aaec opeee oex aopo, ocyecx o oocpeoaoe e.

EPEXBAT HATBA PAAOB Haa c epx pao.Aecaepa 3.aa (1955), ycaox coee pax acco oppe ey x paoao aoc in vivo in vitro, pooe pacpocpaee oya oa pe o oe exae ec poeopo ce oceoo ec paa ye epexaa aa coox paao pyx ax poyo paoa o.

Cyecy, oao, ece opae po pa ooc aoo exaa ec poeopo i vivo.

pee ceo c o epexaa paao eo oe pa paepe ex o poeopo:

p oeypo cpae o oy paac a ecoo opo (a, peep 24 /, ce 1 /). poope ppoe aoo exaa a o, o eaeoe eee cpyyp coee ae y eo ypay ax coc, a ae po paey ceoc coee in vivo coocae c a o peo oaoo cocooc apoa paa ox pacopax. Ta, apep, poa, c, po, o, a ooo pa oapooe co co e ee aaop paao in vitro, a pa, ca, pa, oao ocee oaa a eo in vivo.

poope apaaoy exay ae coopaee o o, o oaoe ypeooe coepae poeopo aeo e, e x ee oepa oyaex pacopax, a cocooc peapoa c paaa ea e, e y pax eox eaoo. Cepeoe opaee, aoe, coco o, o paoyceoc epeo, yeox co pyx ooec ax coee peo caec p epexoe o pacopo ee opay, e oa paec paoyceoc cyxo coco.

MEHEHE OCTEHO-BOCCTAHOBTEHOO OTEHAA Bcaao peooee o oooc c aoo ec poeopo co co oceo-occaoeo oeae (Eh) eo. Oapyeo cee e Eh p pee ex poeopo oc. B oceye, oao, aopaop Bcecooo oooecoo epa o oaao, o c ey eo Eh a eo aecea pe cyae oa ooe ocycye. cepe oaa, apep, o cee ce Eh ac o o paoaoo peapaa aaoca (pc.22), .e. coaae c a o yce paoaoo ea p yee oeca ooo poeopa. Oao aa px (pc.22, a) coocaee x c acoc pe e aaoca pe oy o ocyc oppe ey Eh pooye eo.

Puc.22. eeue oucumeo-occmaoumeoo nomeuaa (Eh) nooo emame e npu ympupuo eeuu aaoca (A) u ymuua (5) paux oax:

1 88 /, 2 175 /, 3 350 /, 4 220 /; cmpeo ooae oem oyeu eceo, paoa e aaoca p oe 350 /, oeae o aeoc e, acae epe 15 ( = 2,7) ocaec a o ypoe ooo oo (epe 75 ( == 2,5), a aee Eh a o pe caec aeo (pua 3), o, aaoc , oo copooac ycee a. C pyo copo, p ao oe peapaa (88 /) ca a e ( < 1,2) oapyaec p 15-yo epae ocycye epe 30 , oa a cpo ae Eh oao (pa 1).

Ha pc.22, pecae ee Eh o e eeoo paoao ooe peapaa ya: Eh o e ya caec o ae, p oopx paoa e aaoca co pae (pa 3 a pc. 22, a).

OBEHE POBH HOEHHX SH-P (CPHA OTEA) B oo ce cepeax cceoa ycaoeo, o aaeoe o e poeopo oee paoycooc oeo copooaec yeee coepa x cypx (ox) py. o pocxo e oo p pee oox poeopo, o p ee oaao peyae aoo oc. Ceoaeo, pe e e o pecex oox pyax, a o oe x oeoo coepa, o ao ocoae paccapa cype py a ececee poeop, ypoe oopx aeo cee opeee pa ppoo paoyceoc.

B oy o o pe, oopy eee ox e oceoaeo paa .. paec, ceecy oocee a oppe coepa oo paoyceoc. a oppe oyea cepeax a opoax eax, a eax pecx opao (oc o ceeea), a opax oyxoex eax, a eax, axoxc a pax cax a, paeax o pax , a pyx oeax, paaxc o cee ppoo paoyceoc.

oaaeco cpaeoc cypo oe ee copo ca ae oooc yee ycooc e oye p ce coepa e oex oo c oo pax xecx coee. oc oe ec aoe (~ 1015%) oee coepa oex SHpy, o ecoocao c e oepa oex oo, oaa aoe ece.

B ocee o oaao, o oe peaa paoaoo ea pa poeopo aoc opeeec coepae SH-py oeoo yaoa, pe e oo o pe, o oce oye.

OBEHE OOECOO OHA PAOPECTEHTHOCTȻ Beee opa ex o poeopo copooaec ooo ae ee pax oxecx poecco, a oe oopx pocxo oyee ox. o cyecy, opaoae oex oo oo poe ax oocex ee. pa aee py oe ooec a coee, eee coepa oopx o e cpec xeco a coae oxec o paopeceoc a ce oa ax pecypco opaa.

Ta opao, c oo copo, o e poeopo yeaec coepae oex ao, oaax paoao aoc (cepoo, oa ca), c pyo caec coepae poyo oce o, oaax paoeec ece.

epe x paccapa a oee poeop, ope a oee paocecaop. poe oo, oee a, coaco paaeo oe pe, apy c apaooec (ocec) exao ec apy ccey ecx yeoo, opopyy, a eco, eooe eee, ce yeox co, o, poaeoc epa pye ae eoe poecc, epeo x, a o ocypyec aopa oe oeoo oa paopeceoc, cocoe paopeceoo eaoa.

OXMEC O, BBAEM ATHM AEHTAM Bea ooc exaa aoo ec pooo pya cepocoepax poeopo. Opaaec ae a c aoo ea oo c ee, pocxo o x ece eax. Oaaoc, o pae opooece yoae c oppepy o pee cee paeoc c a eo. cy ax co oocc: poae eaoecx pea, ceoee pc oxopx pae apca, apyee poaeoc aaecx epa pye apye. oec x ee, oyx aae oxecoo oa, aac oo ex SH-coee x oepa, oope oaa ey ay.

B aee o oaao, o oxec o oae e oo p ae eo SH-coee, o p ec pyx paoax aeo, o ao ocoae peoo, o eo c c oae opee eo e cyaa. o oaao, o pauonpomemop cnoco nepeoum paue uoxuuecue cucme cocmo ue noeo pauopeucmemocmu.

cy ax cce, xc aoee paoyce, oocc opoe exa ocea H, epoe ocoppoae, oceoe ocoppoae oxopx p.

He apaa opoca o exae oxecoo oa, noeue pauopeucmemocmu emo npunucaemc yeueu umeocmu nepuoa penapauu c c o aeee eooo eaoa.

oec exa oo e, po yee oea epeao peapa oeax opee eo, aee peoe .X.yco (1977). Coaco eo pecae oxec o, aac p ee paopoeopo, aoc pyx aeo, ac cya oe ecneuueco peauu emo a ecmue x nopeaux aemo. Cy aoo exaa coco ceye. B ee coepc oo ooeypx coee, oope epaoepo pacpeee pax oceax oaaecoo peyya opaoax. x oapeaa oepaec cceo ypeox epa, pooecyx yooy paa oepa x eec ee. B ope y ypaoeaec ao oe epeoco eec epaa po oepaox paeo.

Mopye ae o-paoy a y a pacop, paoece caec, apyaec oapeaa ooeypx coee, o pacpocpac o ce ee, epy pa cox oax oepax. B peyae pyc epeae poecc -a yee oopaoo ooc eox oey cece oeo acop a x ooeypx eec, o poec pax oaaex eceeco pea ee copoce epeax pea, poaeoc, popaaeoc a pace p. C o pea c oae opee ocec cey opao. Paaooe opaee yax cpyyp, aee pepoyy e eo, oae aae a oeaoe, oopoe aee o peayec, o peappyec. oe cxo opeeec peyao oype x yx poecco, yx oopeeo. Ec copoc x cooca, o oe e ye oe ycee o ce oec, o-paoy a copoc x poecco. p pa eceeco pea aeec copoc a peaa, a peapa oeax opee, oao pao cee, acoc o ppo ecyeo aea yco eo pee. B cyae oeo opoe poecco peaa o peappyex opee yeaec (aa). B opao cyae opeee ycaec.

Ta opao, ocaee ycee paaooo opee eo e coc poc opao oxec poecca, a ca c eaoec ee, ac, co oepe, o ox eeecx ooecx ocoeoce eo aopo cpe.

B ocee o oye oocee ae, ceecye o acoc ey eoc pooyeo a yopoae epeax cce ocpaaoo peapa.

ATA COPOH ET epcaoc copooo ea y pax ooecx oeo eae o cpeee ox cceoaee a ae ca c exa ec oca poeopo, e oee, o p ae e poeopa acaa ea copooo ea py pyy.

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